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Facial transplantation: historical developments and future directions

Published online by Cambridge University Press:  23 March 2015

G L Garrett ,
I Beegun  and
A D'souza
G L Garrett*
Affiliation:
ENT Department, Lewisham Health Care NHS Trust, London, UK
I Beegun
Affiliation:
ENT Department, Royal Free London NHS Foundation Trust, UK
A D'souza
Affiliation:
ENT Department, Lewisham Health Care NHS Trust, London, UK
*
Address for correspondence: Dr Giorgia Louise Garrett, ENT department, Lewisham Hospital NHS Trust, London SE13 6LH, UK E-mail: giorgiagarrett@doctors.org.uk
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Abstract

Objective:

To present the clinical outcomes obtained by the first facial transplant teams worldwide, reviewing current practice and addressing controversies.

Methods:

A bibliographic search of Medline and Embase databases was performed, and a comparative analysis of all articles published from 1980 to the present was conducted. Two independent investigators screened the manuscripts in accordance with pre-defined criteria.

Results:

A total of 12 partial and 5 full facial transplants were recorded in the literature. Procedures included partial and near-total facial myocutaneous flaps, and complex osteomyocutaneous grafts. Fifteen patients had fully vascularised grafts, and two patients died of transplant-related and infectious complications.

Conclusion:

Facial transplantation can restore quality of life and enable the social re-integration of recipients. Results published by the first facial transplant teams are promising. However, long-term reports of aesthetic and functional outcomes are needed to more precisely define outcomes. In addition, significant technical, medical and ethical issues remain to be solved.

Keywords

Facial TransplantationComposite Tissue Allografts
Type
Review Articles
Information
The Journal of Laryngology & Otology , Volume 129 , Issue 3 , March 2015 , pp. 206 - 211
Copyright
Copyright © JLO (1984) Limited 2015 

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