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Functional magnetic resonance imaging in coronavirus disease 2019 induced olfactory dysfunction

Published online by Cambridge University Press:  05 October 2023

Kamyar Iravani ,
Behzad Malekpour Open the ORCID record for Behzad Malekpour [Opens in a new window] ,
Alireza Rasekhi ,
Ali Faramarzi Open the ORCID record for Ali Faramarzi [Opens in a new window] ,
Amir Soltaniesmaeili ,
Behnaz Golkhar ,
Farimah Jahanandish  and
Amirhossein Babaei Open the ORCID record for Amirhossein Babaei [Opens in a new window]
Kamyar Iravani
Affiliation:
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
Behzad Malekpour*
Affiliation:
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
Alireza Rasekhi
Affiliation:
Medical Imaging Research Center (‘MIRC’), Department of Radiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Ali Faramarzi
Affiliation:
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
Amir Soltaniesmaeili
Affiliation:
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
Behnaz Golkhar
Affiliation:
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
Farimah Jahanandish
Affiliation:
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran
Amirhossein Babaei
Affiliation:
Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Shiraz, Iran Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran
*
Corresponding author: Behzad Malekpour; Email: bhzdmlkpr@gmail.com
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Abstract

Objective

To evaluate the functional magnetic resonance imaging changes in the olfactory structures of coronavirus disease 2019 patients experiencing olfactory dysfunction.

Methods

This study included patients aged 25–65 years who presented with a sudden loss of smell, confirmed coronavirus disease 2019 infection, and persistent olfactory dysfunction for a minimum of 2 months without any treatment.

Results

Irrespective of the side of brain activation, the analysis of the cumulative maximum diameter of the activation zones revealed significantly lower activation in the upper frontal lobe (p = 0.037) and basal ganglia (p = 0.023) in olfactory dysfunction patients. Irrespective of the side of activation, the analysis of the number of activation points demonstrated significantly lower activation in the upper frontal lobe (p = 0.036) and basal ganglia (p = 0.009) in olfactory dysfunction patients.

Conclusion

Patients with coronavirus-triggered olfactory dysfunction exhibited lower activity in their basal ganglia and upper frontal lobe.

Keywords

Coronavirusdiagnostic imagingmagnetic resonance imagingsmellquality of life
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 138 , Issue 2 , February 2024 , pp. 178 - 183
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Behzad Malekpour takes responsibility for the integrity of the content of the paper

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