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Immune imbalance of regulatory T/type 2 helper cells in the pathogenesis of allergic rhinitis in children

Published online by Cambridge University Press:  01 December 2015

R Sun ,
X-Y Tang  and
Y Yang
R Sun
Affiliation:
Department of Physical Examination, First Affiliated Hospital of Chongqing Medical University, Chongqing, China
X-Y Tang*
Affiliation:
Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, China Pediatric Research Institute of Chongqing Medical University, Chongqing, China National Key Disciplinary Areas of Pediatrics, Ministry of Education, Chongqing, China
Y Yang
Affiliation:
Department of Otolaryngology, Children's Hospital of Chongqing Medical University, Chongqing, China Pediatric Research Institute of Chongqing Medical University, Chongqing, China National Key Disciplinary Areas of Pediatrics, Ministry of Education, Chongqing, China
*
Address for correspondence: Dr Xin-Ye Tang, Department of Otorhinolaryngology, First Affiliated Hospital of Chongqing Medical University, No. 136, Zhongshan 2nd Road, Yuzhong District, Chongqing, China Fax: +86 023 89012981 E-mail: ent2002@163.com
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Abstract

Objectives:

To determine the role of regulatory T/type 2 helper cell-mediated immune imbalance in the pathogenesis of allergic rhinitis and examine the association between clinical severity and regulatory T/type 2 helper cell-mediated immune imbalance.

Methods:

Levels of interleukins 4 and 5 and transforming growth factor β1, and expression of FOXP3 and GATA3 (which are functionally related to regulatory T and type 2 helper cells, respectively), were evaluated in 46 allergic rhinitis patients and 42 healthy subjects.

Results:

Compared to controls, allergic rhinitis patients showed significantly higher interleukin 4 and 5 levels, but lower transforming growth factor β1 levels. Furthermore, FOXP3 messenger RNA expression was lower in allergic rhinitis patients, while GATA3 messenger RNA and protein expression was significantly higher. Regulatory T/type 2 helper cell ratio was inversely correlated with clinical symptom scores.

Conclusion:

Regulatory T/type 2 helper cell immune imbalance may contribute to allergic rhinitis development. These findings provide a new insight into disease pathogenesis and potential therapeutic approaches.

Keywords

Allergic RhinitisRegulatory T CellsTh2 CellsFOXP3 ProteinHumanGATA3 Protein
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 130 , Issue 1 , January 2016 , pp. 89 - 94
Copyright
Copyright © JLO (1984) Limited 2015 

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