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Laryngeal necrosis after combined chemotherapy and radiation therapy

Published online by Cambridge University Press:  29 June 2007

Mamoru Miyaguchi ,
Hitoshi Takashima  and
Takeshi Kubo
Mamoru Miyaguchi*
Affiliation:
Department of Otorhinolaryngology, Osaka University School of Medicine, 2-2 Yamada-oka Suita-shi, Osaka 565, Japan.
Hitoshi Takashima
Affiliation:
Department of Radiology, Kagawa Medical School, 1750–1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761–07, Japan.
Takeshi Kubo
Affiliation:
Department of Otorhinolaryngology, Osaka University School of Medicine, 2-2 Yamada-oka Suita-shi, Osaka 565, Japan.
*
Address for correspondence: Mamoru Miyaguchi, M.D., Department of Otorhinolaryngology, Osaka University School of Medicine, 2-2 Yamada-oka Suita-shi, Osaka 565, Japan. Fax: 06-879-3959
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Abstract

Post-radiation necrosis of the larynx is a major complication after irradiation and has become rare. Recently, combined chemotherapy and radiation therapy has been introduced for head and neck tumours. The authors report a case of laryngeal necrosis after combination therapy for a patient with cervical lymph node metastases of nasopharyngeal carcinoma and review the literature on late laryngeal necrosis. Although radiation-induced laryngeal necrosis has become a rare complication, the combination of chemotherapy and radiation therapy may increase its incidence. We should always consider it as a possible late complication and treat it appropriately.

Keywords

Laryngeal cartilagesNecrosisRadiotherapyChemotherapy
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 111 , Issue 8 , August 1997 , pp. 763 - 765
Copyright
Copyright © JLO (1984) Limited 1997

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