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Management of locally advanced T3–4 glottic laryngeal carcinomas

Published online by Cambridge University Press:  02 July 2018

R Smee ,
J R Williams  and
D P Kotevski
R Smee
Affiliation:
Department of Radiation Oncology, Prince of Wales Cancer Centre, Randwick, New South Wales, Australia UNSW Clinical Teaching School, Prince of Wales Hospital, Randwick, New South Wales, Australia Department of Radiation Oncology, Tamworth Base Hospital, New South Wales, Australia
J R Williams*
Affiliation:
Department of Radiation Oncology, Prince of Wales Cancer Centre, Randwick, New South Wales, Australia UNSW Clinical Teaching School, Prince of Wales Hospital, Randwick, New South Wales, Australia
D P Kotevski
Affiliation:
Department of Radiation Oncology, Prince of Wales Cancer Centre, Randwick, New South Wales, Australia
*
Author for correspondence: Dr Janet R Williams, Department of Radiation Oncology, Prince of Wales Cancer Centre, Level 2 High Street, Randwick, NSW 2031, Australia E-mail: Janet.Williams@health.nsw.gov.au Fax: +61 2 9382 5170
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Abstract

Objectives

To assess five-year local control and ultimate local control rates of patients treated for locally advanced T3–4 glottic carcinoma with surgery only, radiotherapy only, or surgery plus radiotherapy. Cancer-specific survival, overall survival and rates of malignancy development were also assessed.

Methods

A retrospective review was conducted on patients from 1967 to 2015, with analysis of local control, ultimate local control, overall survival and cancer-specific survival performed using Kaplan–Meier and Cox regression.

Results

Of 169 eligible patients, the majority (59 per cent) were treated with surgery plus radiotherapy, with laryngectomy being the most common surgical procedure. Local control and ultimate local control rates were higher with surgery only (94.1 per cent) and surgery plus radiotherapy (87.9 and 86.8 per cent respectively), compared to radiotherapy only (46.8 and 52.4 per cent) (both p < 0.001). Cancer-specific survival, overall survival and malignancy development did not differ between groups.

Conclusion

Surgery, with or without radiotherapy, offers significantly higher five-year local control and ultimate local control for patients with advanced glottic carcinoma, compared to radiotherapy only.

Keywords

GlottisTNM StagingSquamous Cell CarcinomaTreatment OutcomesRecurrence
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 132 , Issue 7 , July 2018 , pp. 642 - 650
Copyright
Copyright © JLO (1984) Limited, 2018 

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Footnotes

Dr J R Williams takes responsibility for the integrity of the content of the paper

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