Hostname: page-component-7479d7b7d-t6hkb Total loading time: 0 Render date: 2024-07-12T13:08:14.575Z Has data issue: false hasContentIssue false
  • English
  • Français

Nasopharyngeal amyloidosis: an unusual cause for epistaxis

Published online by Cambridge University Press:  16 June 2009

M A Oluk  and
J Murphy
M A Oluk*
Affiliation:
Department of Haematology, West Wales General Hospital, Carmarthen, Wales, UK
J Murphy
Affiliation:
Department of Haematology, West Wales General Hospital, Carmarthen, Wales, UK
*
Address for correspondence: Dr Margaret Atim Oluk, Flat 1, 4A Chalybeate Street, Aberystwyth, Wales SY23 1HS, UK. Fax: 01970 625 059 E-mail: Oluk2000@hotmail.co.uk
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective:

We report the first case of nasal and nasopharyngeal amyloidosis secondary to multiple myeloma; this case also represents the fourth report of systemic nasal or nasopharyngeal amyloidosis.

Method:

Case report and review of the world literature concerning nasal and nasopharyngeal amyloidosis epidemiology, presentation and management.

Results:

Nasal and nasopharyngeal amyloidosis is rare. The presentation, clinical course and treatment are discussed for the presented patient. The amyloid tumour, which recurred in correlation with the progressive transformation of the multiple myeloma, was treated surgically. Subsequent localised radiotherapy decreased the size and growth rate of the tumour.

Conclusion:

Amyloid should be considered as a cause of resistant or recurrent epistaxis provided a mass lesion is seen on radiological imaging. Radiotherapy may be a treatment option in nasal and nasopharyngeal amyloidosis.

Keywords

Nasal CavityNasopharynxAmyloidMyeloma
Type
Clinical Records
Information
The Journal of Laryngology & Otology , Volume 124 , Issue 2 , February 2010 , pp. 209 - 212
Copyright
Copyright © JLO (1984) Limited 2009

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Kramer, R, Som, ML. Local tumor-like deposits of amyloid. Arch Otolaryngol 1935;21:324–34CrossRefGoogle Scholar
2Ottosen, BG. Isolated amyloidosis of the nose, report of a case. Acta Otolaryngol 1953;45:59–61CrossRefGoogle Scholar
3Garrett, JA. Amyloid deposits in the nose and maxillary sinuses, report of a case. Arch Otolaryngol 1968;87:103–4CrossRefGoogle ScholarPubMed
4Johner, CH, Widen, AH, Sahgal, S. Amyloidosis of the head and neck. Trans Am Acad Ophthal Otolaryngol 1972;76:1354–5Google ScholarPubMed
5Elcock, HW, Grimaldi, P. Post-nasal obstruction by amyloid, secondary to Waldenstrom's macroglobulinaemia. J Laryngol Otol 1972;86:1075–9CrossRefGoogle ScholarPubMed
6Prathap, K, Looi, LM, Prasad, U. Localized amyloidosis in nasopharyngeal carcinoma. Histopathology 1984;8:27–34CrossRefGoogle ScholarPubMed
7Simpson, GT, Strong, S, Skinner, M, Cohen, AS. Localised amyloidosis of the head and neck and upper aerodigestive and lower respiratory tracts. Ann Otol Rhinol Laryngol 1984;93:374–9CrossRefGoogle ScholarPubMed
8Zakzouk, MS. Clinical records: an unusual aetiology of unilateral glue ear in a child. J Laryngol Otol 1984;98:519–22CrossRefGoogle Scholar
9Dubey, SP, Mehra, YN, Banerjee, AK, Mann, SBS, Garg, K, Nehru, VI. Nasal involvement in systemic amyloidosis. J Otol Laryngol 1988;102:1153–5CrossRefGoogle ScholarPubMed
10Mufarrij, AA, Busaba, NY, Zaytoun, GM, Gallo, GR, Feiner, HD. Primary localised amyloidosis of the nose and paranasal sinuses, a case report with immunohistochemical observations and a review of the literature. Am J Surg Pathol 1990;14:379–83CrossRefGoogle Scholar
11Gean-Marton, AD, Kirsch, CFE, Gilbert Vezina, L, Weber, AL. Focal amyloidosis of the head and neck: evaluation with CT and MR imaging. Radiology 1991;181:521–5CrossRefGoogle ScholarPubMed
12Hegarty, JL, Rao, VM. Amyloidoma of the nasopharynx: CT and MR findings. AJNR Am J Neuroradiol 1993;14:215–18Google ScholarPubMed
13Panda, NK, Sharma, SC, Mann, SBS, Radotra, BD. Localised amyloidosis of the nasopharynx. ENT 1994;73:335–6Google ScholarPubMed
14Lesserman, JA, Finn, G. Endoscopic treatment of amyloidosis of the nasopharynx. Am J Rhinol 1995;9:43–7CrossRefGoogle Scholar
15Dominguez, S, Wienberg, P, Claros, P, Claros, A, Vila, J. Primary localized nasopharyngeal amyloidosis; a case report. Int J Pediatr Otorhinolaryngol 1996;36:61–7CrossRefGoogle ScholarPubMed
16Zundel, RS, Pyle, GM, Voytovich, M. Head and neck manifestations of amyloidosis. Otolaryngol Head Neck Surg 1999;120:553–7Google ScholarPubMed
17Lim, JS, Lebowitz, RA, Jacobs, JB. Primary amyloidosis presenting as a nasopharyngeal mass. Am J Rhinol 1999;13:209–12CrossRefGoogle ScholarPubMed
18Pitkaranta, A, Malmberg, H. Localized amyloid tumor of the nasopharynx. Otolaryngol Head Neck Surg 2000;122:309–10CrossRefGoogle ScholarPubMed
19Tsikoudas, A, Martin-Hirsch, DP, Woodhead, CJ. Primary sinonasal amyloidosis. J Laryngol Otol 2001;115:55–6CrossRefGoogle ScholarPubMed
20Pang, KP, Chee, LW, Busmanis, I. Amyloidoma of the nose in a paediatric patient: a case report. Am J Otolaryngol 2001;22:138–41CrossRefGoogle Scholar
21Patel, A, Pambuccian, A, Maisel, R. Nasopharyngeal amyloidosis. Am J Otolaryngol 2002;23:308–11CrossRefGoogle ScholarPubMed
22Fatterpeckar, G, Kao, CH, Chen, CY, Som, PM, Chin, SC. Amyloidosis concurrently involving the sinonasal cavities and larynx. AJNR Am J Neuroradiol 2004;25:636–8Google Scholar
23Zhuang, YL, Tsai, TL, Lin, CZ. Localised amyloid deposition in the nasopharynx and neck, mimicking nasopharangeal carcinoma with neck metastasis. J Chin Med Assoc 2005;68:142–5CrossRefGoogle Scholar
24Ling, X, Bai-qiang, C, Xu, Z, Zhu, YJ. Respiratory manifestations in amyloidosis. Chin Med J 2005;118:2027–33Google Scholar
25Zhao, XY, Jia, JD, Wang, BE, Ou, XJ, Qian, LX, Zhang, FK et al. Clinical features of 30 cases of amyloidosis [in Chinese]. Chin Med J 2005;13:42–4Google ScholarPubMed
26Niutin, RG. Amyloidosis of the nasopharynx [in Russian]. Vestn Otorinolaringol 1973;35:94–5Google Scholar
27Zakrzewski, A, Sowinski, H. A case of localized type of amyloidosis restricted to the nasopharynx [in Polish]. Otolaryngol Pol 1970;24:67–70Google Scholar
28Strunski, V, Goin, M, Guillem, I. Amyloidosis of the nasopharynx. Apropos of a case [in French]. Ann Otolaryngol Chir Cervicofac 1991;108:49–51Google ScholarPubMed
29Kumagami, H, Matzumura, T, Aoki, S. A case of nasopharyngeal amyloidosis [in German]. Nippon Jibiinkoka Gakkai Kaiho 1989;92:165–8CrossRefGoogle ScholarPubMed
30Knobber, D, Niehaus, H, Jautzke, G. Localized amyloidosis of the ENT area [in German]. HNO 1994;42:750–3Google ScholarPubMed
31Heinritz, H, Kraus, T, Iro, H. Localized amyloidosis in the area of the head-neck [in German]. HNO 1994;42:744–9Google ScholarPubMed
32O'Sullivan, P, Muller, NL. Pulmonary and nodal multiple myeloma mimicking lymphoma. Br J Radiol 2006;79:25–7CrossRefGoogle ScholarPubMed
33Smith, AS, Wisloff, F, Samson, D, UK Myeloma Forum, Nordic Myeloma Study Group, British Committee for Standards in Haematology. Guidelines on the diagnosis and managenment of multiple myeloma 2005. Br J Haematol 2006;132:410–51CrossRefGoogle Scholar
34Kumar, V, Abbas Abul, K, Fausto, N. Robbins and Coltran Pathologic Basis of Disease, 7th edn. St. Louis, Mo: Elsevier, 2005;260Google Scholar
35Bird, J, Cavenagh, J. Guidelines on the diagnosis and management of AL amyloidosis. UK Myeloma Forum BJH Guidelines 2004;125:681–700Google Scholar
36Singer, CR. ABC of clinical haematology: multiple myeloma and related conditions. BMJ 1997;314:960–3CrossRefGoogle ScholarPubMed
37Gillmore, JD, Hawkins, PN. Amyloidosis and the respiratory tract. Thorax 1999;54:444–51CrossRefGoogle ScholarPubMed