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Pre-habilitation with intratympanic gentamicin in vestibular schwannomas: a systematic review

Published online by Cambridge University Press:  26 April 2023

T Potdar  and
G Kontorinis Open the ORCID record for G Kontorinis [Opens in a new window]
T Potdar
Affiliation:
Medical School, University of Glasgow, Scotland, UK
G Kontorinis*
Affiliation:
Medical School, University of Glasgow, Scotland, UK Department of Otorhinolaryngology, Queen Elizabeth University Hospital, Glasgow, Scotland, UK
*
Author for correspondence: Prof Georgios Kontorinis, Department of Otorhinolaryngology – Skull Base Unit, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow G51 4TF, Scotland, UK E-mail: gkontorinis@gmail.com
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Abstract

Objective

To assess whether pre-habilitation with intratympanic gentamicin can accelerate vestibular compensation following vestibular schwannoma resection.

Methods

Seventeen studies were retrieved from the databases Medline, PubMed, Frontiers, Cochrane Library, Cambridge Core and ScienceDirect. Eight of the 17 studies met our criteria; the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used. Heterogeneity, risk of bias and effect on post-operative recovery were assessed.

Results

Four of the eight studies showed a statistically positive effect of pre-habilitation with gentamicin on the post-operative recovery process; the remainder also reported benefits, although not statistically significant. No study reported negative effects. Limitations were linked mostly to the limited number of enrolled patients and the outcome assessment methods.

Conclusion

Fifty per cent of the studies found a statistically positive effect of pre-habilitation with gentamicin prior to vestibular schwannoma resection. While the results are promising, due to the limited numbers further prospective studies are required to strengthen the evidence.

Keywords

Acoustic NeuromaGentamicinRecoverySurgeryVestibular
Type
Review Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 9 , September 2023 , pp. 985 - 991
Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Prof Kontorinis takes responsibility for the integrity of the content of the paper

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