Hostname: page-component-7479d7b7d-68ccn Total loading time: 0 Render date: 2024-07-12T04:24:57.018Z Has data issue: false hasContentIssue false
  • English
  • Français

Quail egg homogenate with zinc as adjunctive therapy in seasonal allergic rhinitis: a randomised, controlled trial

Published online by Cambridge University Press:  18 May 2022

C Andaloro Open the ORCID record for C Andaloro [Opens in a new window] ,
A M Saibene  and
I La Mantia
C Andaloro*
Affiliation:
Unit of Otorhinolaryngology, Department of Medical Sciences Surgical and Advanced Technologies ‘GF Ingrassia’, University of Catania, Catania, Italy
A M Saibene
Affiliation:
Otolaryngology Unit, Azienda Socio Sanitaria Territoriale Santi Paolo e Carlo, Department of Health Sciences, University of Milan, Milano, Italy
I La Mantia
Affiliation:
Unit of Otorhinolaryngology, Department of Medical Sciences Surgical and Advanced Technologies ‘GF Ingrassia’, University of Catania, Catania, Italy
*
Author for correspondence: Dr C Andaloro, Unit of Otorhinolaryngology, Department of Medical Sciences Surgical and Advanced Technologies ‘GF Ingrassia’, University of Catania, Piazza Università, Catania 95124, Italy E-mail: cla.anda@gmail.com Fax: +39 0916 763 409
Get access Rights & Permissions [Opens in a new window]

Abstract

Objective

Because most available treatments for managing seasonal allergic rhinitis show some side effects without reducing recurrence, natural anti-allergic products could represent an interesting treatment addition. This study aimed to analyse the efficacy and tolerance of quail egg as adjunctive therapy in seasonal allergic rhinitis.

Method

In a Consolidated Standards of Reporting Trials compliant framework, patients with seasonal allergic rhinitis were prospectively randomised to receive mometasone nasal spray for four weeks or the same topical corticosteroid therapy plus commercially available oral quail egg and zinc tablets.

Results

Forty patients were enrolled. The mometasone + quail egg and zinc tablets group showed a greater reduction in nasal itching, sneezing and total nasal symptom scores than the mometasone nasal spray only group. A higher proportion of participants in the mometasone + quail egg and zinc tablets group had good rhinitis control than in the mometasone nasal spray only group, with no need for rescue medications.

Conclusion

Despite the need for a further larger study, quail egg preliminarily appears to be an effective adjunct to topical steroid therapy in seasonal allergic rhinitis.

Keywords

Seasonal Allergic RhinitisQuailAnti-Allergic AgentsMometasone Furoate
Type
Main Article
Information
The Journal of Laryngology & Otology , Volume 137 , Issue 4 , April 2023 , pp. 432 - 437
Copyright
Copyright © The Author(s), 2022. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

Dr C Andaloro takes responsibility for the integrity of the content of the paper

References

Katelaris, CH, Lee, BW, Potter, PC, Maspero, JF, Cingi, C, Lopatin, A et al. Prevalence and diversity of allergic rhinitis in regions of the world beyond Europe and North America. Clin Exp Allergy 2012;42:186–207CrossRefGoogle ScholarPubMed
Brożek, JL, Bousquet, J, Agache, I, Agarwal, A, Bachert, C, Bosnic-Anticevich, S et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision. J Allergy Clin Immunol 2017;140:950–8CrossRefGoogle ScholarPubMed
Schwindt, CD, Settipane, R. Allergic rhinitis (AR) is now estimated to affect some 1.4 billion people globally and continues to be on the rise. Am J Rhinol Allergy 2012;26(suppl 1):S1CrossRefGoogle ScholarPubMed
Lunn, M, Craig, T. Rhinitis and sleep. Sleep Med Rev 2011;15:293–9CrossRefGoogle ScholarPubMed
Zuberbier, T, Lötvall, J, Simoens, S, Subramanian, S, Church, MK. Economic burden of inadequate management of allergic diseases in the European Union: a GA(2) LEN review. Allergy 2014;69:1275–9CrossRefGoogle Scholar
Yoo, KH, Ahn, HR, Park, JK, Kim, JW, Nam, GH, Hong, SK et al. Burden of respiratory disease in Korea: an observational study on allergic rhinitis, asthma, copd, and rhinosinusitis. Allergy Asthma Immunol Res 2016;8:527–34CrossRefGoogle ScholarPubMed
Sardana, N, Craig, TJ. Congestion and sleep impairment in allergic rhinitis. Asian Pac J Allergy Immunol 2011;29:297–306Google ScholarPubMed
Theoharides, TC, Kalogeromitros, D. The critical role of mast cells in allergy and inflammation. Ann N Y Acad Sci 2006;1088:78–99CrossRefGoogle ScholarPubMed
Baena-Cagnani, CE. Safety and tolerability of treatments for allergic rhinitis in children. Drug Saf 2004;27:883–98CrossRefGoogle ScholarPubMed
Hardjojo, A, Shek, LP, van Bever, HP, Lee, BW. Rhinitis in children less than 6 years of age: current knowledge and challenges. 2012;2:90 Asia Pac Allergy 2011;1:115–22CrossRefGoogle ScholarPubMed
Greiner, AN, Hellings, PW, Rotiroti, G, Scadding, GK. Allergic rhinitis. Lancet 2011;378:2112–22CrossRefGoogle ScholarPubMed
Turner, PJ, Kemp, AS. Allergic rhinitis in children. J Paediatr Child Health 2012;48:302–10CrossRefGoogle ScholarPubMed
Al Sayyad, JJ, Fedorowicz, Z, Alhashimi, D, Jamal, A. Topical nasal steroids for intermittent and persistent allergic rhinitis in children. Cochrane Database Syst Rev 2007;(1):CD003163Google ScholarPubMed
Knoops, L, Louahed, J, Van Snick, J, Renauld, J–C. IL-9 promotes but is not necessary for systemic anaphylaxis. J Immunol 2005;175:335–41CrossRefGoogle Scholar
Truffier, J. Approche therapeutique de la maladie allergique par ingestion d'oeufs de caille. La Clinique 1978;22:2–4Google Scholar
Benichou, AC, Armanet, M, Bussière, A, Chevreau, N, Cardot, JM, Tétard, J. A proprietary blend of quail egg for the attenuation of nasal provocation with a standardized allergenic challenge: a randomized, double-blind, placebo-controlled study. Food Sci Nutr 2014;2:655–63CrossRefGoogle ScholarPubMed
Feeney, RE, Means, GE, Bigler, JC. Inhibition of human trypsin, plasmin, and thrombin by naturally occurring inhibitors of proteolytic enzymes. J Biol Chem 1969;244:1957–60CrossRefGoogle ScholarPubMed
Bruttman, G. Ovix. Quail egg homogenate: a clinical evaluation. La Med Biol 1995;2:25–9Google Scholar
Ellis, AK, Soliman, M, Steacy, L, Boulay, M, Boulet, L, Keith, PK et al. The Allergic Rhinitis - Clinical Investigator Collaborative (AR-CIC): nasal allergen challenge protocol optimization for studying AR pathophysiology and evaluating novel therapies. Allergy Asthma Clin Immunol 2015;11:16CrossRefGoogle ScholarPubMed
Nathan, RA, Dalal, AA, Stanford, RH, Meltzer, EO, Schatz, M, Derebery, J et al. Qualitative Development of the Rhinitis Control Assessment Test (RCAT), an instrument for evaluating rhinitis symptom control. Patient 2010;3:91–9CrossRefGoogle ScholarPubMed
Ottaviano, G, Fokkens, WJ. Measurements of nasal airflow and patency: a critical review with emphasis on the use of peak nasal inspiratory flow in daily practice. Allergy 2016;71:162–74CrossRefGoogle ScholarPubMed
Syrigou, E, Psarros, F, Makris, M, Grapsa, D, Syrigos, K. Efficacy of a quail eggs-based dietary supplement for allergic rhinitis: results of a single-arm trial. J Diet Suppl 2021;18:17–30CrossRefGoogle ScholarPubMed
Mygind, N, Dahl, R, Nielsen, LP, Hilberg, O, Bjerkex, T. Effect of corticosteroids on nasal blockage in rhinitis measured by objective methods. Allergy 1997;52:39–44CrossRefGoogle ScholarPubMed
Aaronson, DW. Side effects of rhinitis medications. J Allergy Clin Immunol 1998;101:S379–82CrossRefGoogle ScholarPubMed
Prelipcean, A, Prelipcean, A, Teuşan, V. Investigations on the structure, chemical composition and caloricity of the quail eggs, deposited at the plateau phase of the laying period. Lucrari Stiintifice–Seria Zootehnie 2012;57:113–20Google Scholar
Vergnaud, S, Bruttmann, G, Louwagie, M, Morel, F. Effetto inibitorio dell'ovomucoide di uovo di quaglia giapponese sull'attività di tripsina ed elastasi umane. La Med Biol 2007;2:5–13Google Scholar
Widmer, F, Hayes, PJ, Whittaker, RG, Kumar, R. Substrate preference profiles of proteases released by allergenic pollens. Clin Exp Allergy 2000;30:571–6CrossRefGoogle ScholarPubMed
Lianto, P, Han, S, Li, X, Ogutu, FO, Zhang, Y, Fan, Z et al. Quail egg homogenate alleviates food allergy induced eosinophilic esophagitis like disease through modulating PAR-2 transduction pathway in peanut sensitized mice. Sci Rep 2018;8:1049CrossRefGoogle ScholarPubMed
Zalewski, PD, Truong-Tran, AQ, Grosser, D, Jayaram, L, Murgia, C, Ruffin, RE. Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review. Pharmacol Ther 2005;105:127–49CrossRefGoogle ScholarPubMed
Novick, SG, Godfrey, JC, Pollack, RL, Wilder, H. Zinc-induced suppression of inflammation in the respiratory tract, caused by infection with human rhinovirus and other irritants. Med Hypotheses 1997;49:347–57CrossRefGoogle Scholar
Demoly, P, Sahla, M, Campbell, AM, Bousquet, J, Crampette, L. ICAM-1 expression in upper respiratory mucosa is differentially related to eosinophil and neutrophil inflammation according to the allergic status. Clin Exp Allergy 1998;28:731–8CrossRefGoogle Scholar
Lu, H, Xin, Y, Tang, Y, Shao, G. Zinc suppressed the airway inflammation in asthmatic rats: effects of zinc on generation of eotaxin, MCP-1, IL-8, IL-4, and IFN-γ. Biol Trace Elem Res 2012;150:314–21CrossRefGoogle ScholarPubMed
Mohamed, NA, Rushdy, M, Abdel-Rehim, ASM. The immunomodulatory role of zinc in asthmatic patients. Cytokine 2018;110:301–5CrossRefGoogle ScholarPubMed
Tolik, D, Poławska, E, Charuta, A, Nowaczewski, S, Cooper, R. Characteristics of egg parts, chemical composition and nutritive value of Japanese quail eggs--a review. Folia Biol (Krakow) 2014;62:287–92CrossRefGoogle ScholarPubMed
Supplementary material: File

Andaloro et al. supplementary material

Andaloro et al. supplementary material
Download Andaloro et al. supplementary material(File)
File 177.9 KB