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Voice outcome after vocal fold injection augmentation with carboxymethyl cellulose versus calcium hydroxyapatite

Published online by Cambridge University Press:  04 March 2020

J T Cohen  and
L Benyamini
J T Cohen*
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Rambam Healthcare Campus, The Technion, Institude of Thechnology, Haifa, Israel
L Benyamini
Affiliation:
Department of Otolaryngology Head and Neck Surgery, Rambam Healthcare Campus, The Technion, Institude of Thechnology, Haifa, Israel
*
Author for correspondence: Dr Jacob T Cohen, Department of Otolaryngology Head and Neck Surgery, Rambam Healthcare Campus, The Technion, Institude of Thechnology, Haifa, Israel E-mail: ja_cohen@rambam.health.gov.il Fax: +972 4777 2772
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Abstract

Background

Vocal fold injection augmentation is a recognised treatment modality for glottic insufficiency. Causes of glottal closure insufficiency include vocal fold paralysis, paresis, atrophy, sulcus vocalis, scarring and vocal fold deficiency after laryngeal surgery. A variety of materials exist for injection augmentation. This study aimed to compare voice improvement after injection augmentation between two injectable materials: carboxymethyl cellulose and calcium hydroxyapatite.

Method

This retrospective study included 66 consecutive patients with glottic insufficiency who underwent injection augmentation.

Results

Among the patients who received their first injection augmentation with carboxymethyl cellulose and their second injection augmentation with calcium hydroxyapatite (n = 28), voice quality improved significantly after both injection augmentations. No significant differences were observed in any of the objective and subjective voice quality measurements examined following carboxymethyl cellulose and calcium hydroxyapatite injections.

Conclusion

Voice improvement after injection augmentation depends mainly on the improvement of glottic closure, rather than the injection material.

Keywords

Vocal Cord ParalysisInjectionsGlottisHoarseness
Type
Main Articles
Information
The Journal of Laryngology & Otology , Volume 134 , Issue 3 , March 2020 , pp. 263 - 269
Copyright
Copyright © JLO (1984) Limited, 2020

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Footnotes

Dr J T Cohen takes responsibility for the integrity of the content of the paper

References

Rosen, CA. Phonosurgical vocal fold injection: procedures and materials. Otolaryngol Clin North Am 2000;33:1087–96CrossRefGoogle ScholarPubMed
King, JM, Simpson, CB. Modern injection augmentation for glottic insufficiency. Curr Opin Otolaryngol Head Neck Surg 2007;15:153–8CrossRefGoogle ScholarPubMed
Nakayama, M, Ford, CN, Bless, DM. Teflon vocal fold augmentation: failures and management in 28 cases. Otolaryngol Head Neck Surg 1993;109:493–8CrossRefGoogle ScholarPubMed
Rubin, HJ. Pitfalls in treatment of dysphonias by intracordal injection of synthetics. Laryngoscope 1965;75:1381–97CrossRefGoogle ScholarPubMed
Misono, S, Merati, AL. Evidence-based practice: evaluation and management of unilateral vocal fold paralysis. Otolaryngol Clin North Am 2012;45:1083–108CrossRefGoogle ScholarPubMed
Kwon, TK, Buckmire, R. Injection laryngoplasty for management of unilateral vocal fold paralysis. Curr Opin Otolaryngol Head Neck Surg 2004;12:538–42CrossRefGoogle ScholarPubMed
Szkiełkowska, A, Miaśkiewicz, B, Remacle, M, Krasnodębska, P, Skarżyński, H. Quality of the voice after injection of hyaluronic acid into the vocal fold. Med Sci Monit 2013;19:276–82Google ScholarPubMed
Lagier, A, Polle-Pelletier, V, Giovanni, A, Marie, JP. Vocal fold medialization: which are the available fillers in France in 2010? Eur Ann Otorhinolaryngol Head Neck Dis 2011;128:99–101CrossRefGoogle ScholarPubMed
Simpson, CB, Amin, MR. Office-based procedures for the voice. Ear Nose Throat J 2004;83:6–9Google ScholarPubMed
Mallur, PS, Rosen, CA. Vocal fold injection: review of indications, techniques, and materials for augmentation. Clin Exp Otorhinolaryngol 2010;3:177–82CrossRefGoogle ScholarPubMed
Mallur, PS, Morrison, MP, Postma, GN, Amin, MR, Rosen, CA. Safety and efficacy of carboxymethylcellulose in the treatment of glottic insufficiency. Laryngoscope 2012;122:322–6CrossRefGoogle ScholarPubMed
Sundaram, H, Voigts, B, Beer, K, Meland, M. Comparison of the rheological properties of viscosity and elasticity in two categories of soft tissue fillers: calcium hydroxylapatite and hyaluronic acid. Dermatol Surg 2010;36(suppl 3):1859–65CrossRefGoogle ScholarPubMed
Kimura, M, Mau, T, Chan, RW. Viscoelastic properties of phonosurgical biomaterials at phonatory frequencies. Laryngoscope 2010;120:764–8CrossRefGoogle ScholarPubMed
Kimura, M, Nito, T, Sakakibara, KI, Tayama, N, Niimi, S. Clinical experience with collagen injection of the vocal fold: a study of 155 patients. Auris Nasus Larynx 2008;35:67–75CrossRefGoogle ScholarPubMed
Kimura, M, Nito, T, Imagawa, H, Tayama, N, Chan, RW. Collagen injection as a supplement to arytenoid adduction for vocal fold paralysis. Ann Otol Rhinol Laryngol 2008;117:430–6CrossRefGoogle ScholarPubMed
Hoffman, H, McCabe, D, McCulloch, T, Jin, SM, Karnell, M. Laryngeal collagen injection as an adjunct to medialization laryngoplasty. Laryngoscope 2002;112:1407–13CrossRefGoogle ScholarPubMed
Upton, DC, Johnson, M, Zelazny, SK, Dailey, SH. Prospective evaluation of office-based injection laryngoplasty with hyaluronic acid gel. Ann Otol Rhinol Laryngol 2013;122:541–6CrossRefGoogle ScholarPubMed
Wang, CC, Chang, MH, Jiang, RS, Lai, HC, De Virgilio, A, Wang, CP et al. Laryngeal electromyography-guided hyaluronic acid vocal fold injection for unilateral vocal fold paralysis: a prospective long-term follow-up outcome report. JAMA Otolaryngol Neck Surg 2015;141:264–71CrossRefGoogle ScholarPubMed
Jang, JY, Lee, G, Ahn, J, Son, YI. Early voice rehabilitation with injection laryngoplasty in patients with unilateral vocal fold palsy after thyroidectomy. Eur Arch Otorhinolaryngol 2015;272:3745–50CrossRefGoogle ScholarPubMed
Rosen, CA, Gartner-Schmidt, J, Casiano, R, Anderson, TD, Johnson, F, Remacle, M et al. Vocal fold augmentation with calcium hydroxylapatite: twelve-month report. Laryngoscope 2009;119:1033–41CrossRefGoogle ScholarPubMed
Rosen, CA, Gartner-Schmidt, J, Casiano, R, Anderson, TD, Johnson, F, Reussner, L et al. Vocal fold augmentation with calcium hydroxylapatite (CaHA). Otolaryngol Head Neck Surg 2007;136:198–204CrossRefGoogle Scholar
Mohammed, H, Masterson, L, Gendy, S, Nassif, R. Outpatient-based injection laryngoplasty for the management of unilateral vocal fold paralysis – clinical outcomes from a UK centre. Clin Otolaryngol 2016;41:341–6CrossRefGoogle ScholarPubMed
Carroll, TL, Rosen, CA. Long-term results of calcium hydroxylapatite for vocal fold augmentation. Laryngoscope 2011;121:313–19CrossRefGoogle ScholarPubMed
Rees, CJ, Mouadeb, DA, Belafsky, PC. Thyrohyoid vocal fold augmentation with calcium hydroxyapatite. Otolaryngol Head Neck Surg 2008;138:743–6CrossRefGoogle ScholarPubMed
Amin, MR. Thyrohyoid approach for vocal fold augmentation. Ann Otol Rhinol Laryngol 2006;115:699–702CrossRefGoogle ScholarPubMed
Laccourreye, O, Papon, J-F, Kania, R, Crevier-Buchman, L, Brasnu, D, Hans, S. Intracordal injection of autologous fat in patients with unilateral laryngeal nerve paralysis: long-term results from the patient's perspective. Laryngoscope 2003;113:541–5CrossRefGoogle ScholarPubMed
Carroll, TL, Rosen, CA. Trial vocal fold injection. J Voice 2010;24:494–8CrossRefGoogle ScholarPubMed
Powell, J, Carding, P, Birdi, R, Wilson, JA. Injection laryngoplasty in the outpatient clinic under local anaesthetic: a case series of sixty-eight patients. Clin Otolaryngol 2014;39:224–7CrossRefGoogle ScholarPubMed
Fritz, MA, Peng, R, Born, H, Cerrati, EW, Verma, A, Wang, B et al. The safety of antithrombotic therapy during in-office laryngeal procedures--a preliminary study. J Voice 2015;29:768–71CrossRefGoogle ScholarPubMed
Andrade Filho, PA, Carrau, RL, Buckmire, RA. Safety and cost-effectiveness of intra-office flexible videolaryngoscopy with transoral vocal fold injection in dysphagic patients. Am J Otolaryngol 2006;27:319–22CrossRefGoogle ScholarPubMed
Yung, KC, Likhterov, I, Courey, MS. Effect of temporary vocal fold injection medialization on the rate of permanent medialization laryngoplasty in unilateral vocal fold paralysis patients. Laryngoscope 2011;121:2191–4CrossRefGoogle ScholarPubMed
Hertegård, S, Hallén, L, Laurent, C, Lindström, E, Olofsson, K, Testad, P et al. Cross-linked hyaluronan versus collagen for injection treatment of glottal insufficiency: 2-year follow-up. Acta Otolaryngol 2004;124:1208–14CrossRefGoogle ScholarPubMed
Zeleník, K, Walderová, R, Kučová, H, Jančatová, D, Komínek, P. Comparison of long-term voice outcomes after vocal fold augmentation using autologous fat injection by direct microlaryngoscopy versus office-based calcium hydroxylapatite injection. Eur Arch Otorhinolaryngol 2017;274:3147–51CrossRefGoogle ScholarPubMed
Shen, T, Damrose, EJ, Morzaria, S. A meta-analysis of voice outcome comparing calcium hydroxylapatite injection laryngoplasty to silicone thyroplasty. Otolaryngol Neck Surg 2013;148:197–208CrossRefGoogle ScholarPubMed
Amir, O, Ashkenazi, O, Leibovitzh, T, Michael, O, Tavor, Y, Wolf, M. Applying the Voice Handicap Index (VHI) to dysphonic and nondysphonic Hebrew speakers. J Voice 2006;20:318–24CrossRefGoogle ScholarPubMed
Bach, KK, Belafsky, PC, Wasylik, K, Postma, GN, Koufman, JA. Validity and reliability of the glottal function index. Arch Otolaryngol Head Neck Surg 2005;131:961–4CrossRefGoogle ScholarPubMed
Hirano, M. Clinical Examination of Voice. New York: Springer, 1981Google Scholar
Boersma, P, Weenink, D. Praat: doing phonetics by computer [computer program]. Version 6.0.37. 2018. In: http://www.praat.org/Google Scholar