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Antithrombotic, antimicrobial activities, and biocompatibility of surface-functionalized titanium

Published online by Cambridge University Press:  05 December 2019

Guannan Zhang ,
Xingyu Zhang ,
Zhiping Sun ,
Xiaohong Yao  and
Xiangyu Zhang
Guannan Zhang*
Affiliation:
College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, People’s Republic of China
Xingyu Zhang*
Affiliation:
College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, People’s Republic of China
Zhiping Sun
Affiliation:
School of Electromechanical and Automobile Engineering, Changzhou Vocational Institute of Engineering, Changzhou 213164, People’s Republic of China
Xiaohong Yao*
Affiliation:
College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, People’s Republic of China
Xiangyu Zhang*
Affiliation:
College of Materials Science and Engineering, Taiyuan University of Technology, Taiyuan 030024, People’s Republic of China
*
a)Address all correspondence to these authors. e-mail: xhyao@tyut.edu.cn
b)e-mail: zhangxiangyu@tyut.edu.cn
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Abstract

Titanium (Ti) has been extensively used in medical devices owing to their low density, high strength, excellent corrosion resistance, and biocompatibility. However, thrombus formation and bacterial infections are still challenges for their application in specific clinical cases. Hence, we have developed a simple, efficient, and stable strategy that endow Ti with anticoagulant and antibacterial properties through chemical bonding and electrostatic bonding. A large number of hydroxyl groups were produced on the surface of Ti by annealing at 500 °C. Then, heparin was immobilized on annealed surface with chemical bonding and chitosan was captured in an electrostatically bound manner by simply soaking in solution. The results indicated that the surface-functionalized Ti exhibited excellent anticoagulant properties by a reduction in platelet adhesion and prolonged blood clotting time. Furthermore, the modified Ti also showed antibacterial properties against both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus).

Keywords

Tiannealingantithrombogenic activitiesantibacterial activitiesbiomaterial
Type
Article
Information
Journal of Materials Research , Volume 34 , Issue 24 , 30 December 2019 , pp. 4056 - 4065
Copyright
Copyright © Materials Research Society 2019 

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