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Discrete-element method application to mixing and segregation model in industrial blending system

Published online by Cambridge University Press:  03 March 2011

Kenji Yamane
Kenji Yamane
Affiliation:
Manufacture Technology Department, Taiho Pharmaceutical Co., Ltd., Tokusima 771-0194, Japan
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Abstract

In the pharmaceutical industries, mixing is a critical process. Pharmaceutical products consist of various components, including active ingredient and excipient. After mixing, we should get a homogeneous mixture to ensure the quality of the final products, such as tablets or capsules. For that reason, segregation is an unwanted phenomena in the mixing process. In this study, discrete-element method (DEM) was applied to investigate the mechanism of segregation in a rotating cylinder; basic equipment for powder mixing. In addition, segregation of particles in a rotating cylinder is a very interesting phenomenon and has captured the curiosity of not only industrial engineers, but also physicists. DEM can simulate segregation in a rotating cylinder three-dimensionally. In particular, radial segregation, which was quickly observed, was quantified by computing the granular temperature of the system. Furthermore, particle migration in axial direction, which may be the source of axial segregation, was also shown by the DEM simulation.

Keywords

DEMSegregationGranular temperature
Type
Articles
Information
Journal of Materials Research , Volume 19 , Issue 2 , February 2004 , pp. 623 - 627
Copyright
Copyright © Materials Research Society 2004

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