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Anticonvulsants and Megaloblastic Anaemia

Published online by Cambridge University Press:  08 February 2018

John Johnson
John Johnson*
Affiliation:
Netherne Hospital, Coulsdon
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Extract

The development of megaloblastic anaemia as a complication of anticonvulsant therapy is now well recognized, and a total of thirty cases has been recorded.

Badenoch (1) reported the first detailed studies of megaloblastic anaemia developing in epileptic patients treated with phenobarbitone and epanutin, whilst Fuld and Moorhouse (6) reported the association with primidone (Mysoline) alone. In all the cases reported, the anaemia responded to folic acid therapy, whilst anticonvulsant drugs were continued.

Type
Original Articles
Information
Journal of Mental Science , Volume 105 , Issue 440 , July 1959 , pp. 819 - 820
Copyright
Copyright © Royal College of Psychiatrists, 1959 

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References

1. Badenoch, J., Proc. Roy. Soc. Med., 1954, 47, 426.Google Scholar
2. Benians, R. C., and Hunter, R. A., J. Ment. Sci., 1957, 103, 606.Google Scholar
3. Chanarin, I., Elmes, B. M., and Mollin, D. L., Brit. Med. J., 1958, ii, 80.CrossRefGoogle Scholar
4. Dawson, D. W., and Johnson, J., ibid., 1958, i, 397.Google Scholar
5. Denborough, M. A., Retief, F. P., and Witts, L. J., ibid., 1958, i, 1213.Google Scholar
6. Fuld, H., and Moorhouse, E. H., ibid., 1956, i, 1021.Google Scholar
7. Girdwood, R. H., and Lenman, J. A. R., ibid., 1956, i, 146 Google Scholar
8. Kidd, P., and Mollin, D. L., ibid., 1957, ii, 974.Google Scholar
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