My Dear Dr. Laycock,—I am sorry that owing to constant occupation of my time by asylum engagements, I have not been able sooner to forward the cases of which I promised you a detailed history. This I have been at some pains in ascertaining as accurately as possible, and regret that I have not been able to put my materials into a more polished form. Both of them seem to be very typical examples of the forms of general paralysis which you differentiate, namely, the alcoholic and diathetic. Each affords a most perfect example of the sequence by which, from a perfect arthritic health, and sound arthritic modes of psychological manifestation, the invasion of paralysis gradually proceeded to sap and extinguish life.