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Preliminary absorbed dose evaluation of two novel 153Sm bone-seeking agents for radiotherapy of bone metastases: comparison with 153Sm-EDTMP

Published online by Cambridge University Press:  08 May 2015

Hassan Yousefnia ,
Samaneh Zolghadri ,
A. Reza Jalilian  and
Zohreh Naseri
Hassan Yousefnia
Affiliation:
Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
Samaneh Zolghadri*
Affiliation:
Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
A. Reza Jalilian
Affiliation:
Nuclear Science and Technology Research Institute (NSTRI), Tehran, Iran
Zohreh Naseri
Affiliation:
School of Chemistry, University College of Science, University of Tehran, Tehran, Iran
*
Correspondence to: Samaneh Zolghadri, Nuclear Science and Technology Research Institute (NSTRI), Tehran, 14155-1339, Iran. Tel: +982188221103. Fax: +982188221105. E-mail: szolghadri@aeoi.org.ir
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Abstract

Aim

The amount of energy deposited on any organ by ionising radiation termed absorbed dose, plays an important role in evaluating the risks associated with the administration of radiopharmaceuticals. In this research work, the absorbed dose received by human organs for 153Sm-TTHMP and 153Sm-PDTMP was evaluated based on biodistribution studies on the Syrian rats.

Materials and methods

153Sm-TTHMP and 153Sm-PDTMP were successfully prepared with radiochemical purity of higher than 99%. The biodistribution of the complexes was investigated within the Syrian rats up to 48 hours post injection. The human absorbed dose of the complexes was estimated by the radiation dose assessment resource method.

Results

The highest absorbed dose for 153Sm-TTHMP and 153Sm-PDTMP was observed in the trabecular bone with 1·085 and 1·826 mGy/MBq, respectively. The bone to other critical organ dose ratio for 153Sm-PDTMP is significantly greater than 153Sm-TTHMP. Also, the bone/red marrow dose ratio for these complexes is comparable with this ratio for 153Sm-EDTMP, as the most clinically used Sm-153 bone pain palliative radiopharmaceutical.

Findings

According to the considerable bone absorbed dose against the insignificant absorbed dose of non-target organs, these complexes can be used as potential bone pain palliative agents in clinical applications.

Keywords

internal dosimetryPDTMPRADAR methodSm-153TTHMP
Type
Original Articles
Information
Journal of Radiotherapy in Practice , Volume 14 , Issue 3 , September 2015 , pp. 252 - 259
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Copyright
© Cambridge University Press 2015 

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