Despite substantial efforts to decrease its prevalence, it is estimated that more than 20% of French women continue to smoke during pregnancy. The aim of this study was to assess the perceived stress and coping strategies used by pregnant smokers when they seek help to stop smoking. Eighty pregnant women were involved. Pregnant women who stated their intention to quit smoking (n= 40) were compared with pregnant nonsmokers (n= 40). All participants filled out the Brief Cope (BC), the Perceived Stress Scale (PSS) and the Hospital Anxiety Depression Scale (HADS). In addition to these self-report scales, pregnant smokers completed the Fagerström Tolerance Questionnaire (FTQ). The results show that pregnant women who smoked used less active coping, planning, and positive framing, considered a good adaptive strength, and had significantly elevated scores on perceived stress and anxiety scales than nonsmokers. This research is the first to provide Brief Cope results for pregnant smokers seeking help to stop smoking linked to perceived stress. The results obtained contribute to the well-known psychosocial factors in maintaining smoking during pregnancy and will be used in the implementation of more effective intervention programs among pregnant women.