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Episodic memory function in advanced aging and early Alzheimer's disease

Published online by Cambridge University Press:  26 February 2009

C. Munro Cullum ,
C. M. Filley  and
E. Kozora
C. Munro Cullum
Affiliation:
Departments of Psychiatry and Neurology, The University of Texas Southwestern Medical Center, Dallas, TX 75235-8898
C. M. Filley
Affiliation:
Departments of NeurologyUniversity of Colorado School of Medicine, Denver, CO 80262 Departments of Psychiatry, University of Colorado School of Medicine, Denver, CO 80262 Denver VA Medical Center, Denver, CO 80220
E. Kozora
Affiliation:
Departments of Psychiatry, University of Colorado School of Medicine, Denver, CO 80262 National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206
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Abstract

Despite some well-documented differences, normal aging and Alzheimer's disease (AD) share a number of common neuropathological and neuropsychological features. Many of the reported differences are largely quantitative in nature and there is often overlap between the respective distributions of these populations. To assess the issue of overlap and distinguishing features in memory functions between these groups, and to minimize aging effects per se, samples of older individuals in good health (ages 75–95 yr) and younger patients in the early stages of AD (age < 75 yr) were selected to be similar in global cognitive functioning. Despite comparable language and visuospatial scores, these preliminary results suggest important qualitative differences in episodic memory functions between these conditions, even when “low-functioning” or “at-risk” controls are compared with early AD patients. These findings furthermore highlight some of the challenges in defining “normality” among the oldest segment of our population. (JINS, 1995, I, 100–103.)

Keywords

Alzheimer's diseaseAgingMemoryNeuropsychology
Type
Rapid Communications
Information
Journal of the International Neuropsychological Society , Volume 1 , Issue 1 , January 1995 , pp. 100 - 103
Copyright
Copyright © The International Neuropsychological Society 1995

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References

Bennett, D.A. & Evans, D.A. (1992). Alzheimer's disease. Disease Monographs, 38, 1–64.Google ScholarPubMed
Bondi, M.W., Monsch, A.U., Galasko, D., Butters, N., Salmon, D.P., & Delis, D.C. (1994). Preclinical cognitive markers of dementia of the alzheimer type. Neuropsychology, 8, 374–384.CrossRefGoogle Scholar
Butters, N., Salmon, D.P., Cullum, C.M., Cairns, P., Troster, A.I., & Jacobs, D. (1988). Differentiation of amnesic and demented patients with the Wechsler Memory Scale-Revised. The Clinical Neuropsychologist, 2, 133–148.CrossRefGoogle Scholar
Crystal, H., Dickson, D., Fuld, P., Masur, D., Scott, R., Mehler, M., Marsdeu, M., Kawas, C., Aronson, M., & Wolfson, L. (1988). Clinico-pathologic studies in dementia: Nonde-mented subjects with pathologically confirmed Alzheimer's disease. Neurology, 38, 1682–1687.CrossRefGoogle ScholarPubMed
Cullum, C.M., Butters, N., Troster, A.I., & Salmon, D. (1990). Normal aging and forgetting rates on the Wechsler Memory Scale-Revised. Archives of Clinical Neuropsychology, 5, 23–30.CrossRefGoogle Scholar
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B. (1987). California Verbal Learning Test: Research Edition. San Antonio: The Psychological Corporation.Google Scholar
Delis, D.C., Massman, P.J., Butters, N., Salmon, D.P., Cermak, L.S., & Kramer, J.H. (1991). Profiles of demented and amnesic patients on the California Verbal Learning Test: Implications for the assessment of memory disorders. Psychological Assessment, 3, 19–26.CrossRefGoogle Scholar
Evans, D.A., Funkenstein, H.H., Albert, M.S., Scherr, I., Cook, N., Chown, M., Hebert, L.I., Hennekens, C.H., & Taylor, J.O. (1989). Prevalence of Alzheimer's Disease in a community population of older persons. Journal of the American Medical Association, 262, 2551–2556.CrossRefGoogle Scholar
Folstein, M.F., Folstein, S.E., & McHugh, P. (1975). “Mini-Mental State”: A practical method for grading the cognitive state of outpatients for the clinician. Journal of Psychiatric Research, 12, 189–198.CrossRefGoogle Scholar
Goodglass, H. & Kaplan, E. (1983). The assessment of aphasia and related disorders. Philadelphia: Lea & Febiger.Google Scholar
Hart, R.P., Kwentus, J.A., Harkins, S.W., & Taylor, R.R. (1988). Rate of forgetting in mild Alzheimer's-type dementia. Brain and Cognition, 7, 31–38.CrossRefGoogle ScholarPubMed
Ivnik, R.J., Malec, J.F., Smith, E.G., Tangalos, E.C., Peter-sen, R.C., Kokmen, E., & Kurland, L.T. (1992). Mayo's older americans normative studies: WMS-R norms for age 56 to 94. The Clinical Neuropsychologist, 6, 49–82.CrossRefGoogle Scholar
Khachaturian, Z.S. (1985). Diagnosis of Alzheimer's Disease. Archives of Neurology, 42, 1097–1105.CrossRefGoogle ScholarPubMed
Mattis, S. (1988). Dementia rating scale. Odessa, FL: Psychological Assessment Resources, Inc..Google Scholar
McKhann, G., Drachman, D., Folstein, M, Katzman, R., Price, D., & Stadlan, E M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939–944.CrossRefGoogle ScholarPubMed
Mitrushina, M., Satz, P., & Van Gorp, W. (1989). Some putative cognitive precursors in subjects hypothesized to be at-risk for dementia. Archives of Clinical Neuropsychology, 4, 323–333.CrossRefGoogle ScholarPubMed
Monsch, A.U., Bondi, M.W., Butters, N., Paulsen, J.S., Salmon, D.P., Brugger, P., & Swenson, M.R. (1994). A comparison of category and letter fluency in Alzheimer's disease and Huntington's disease. Neuropsychology, 8, 25–30.CrossRefGoogle Scholar
Petersen, R.C., Smith, G.E., Ivnik, R.J., Kokmen, E., & Tangalos, E.G. (1994). Memory function in very early Alzheimer's disease. Neurology, 44, 867–872.CrossRefGoogle ScholarPubMed
Roman, G.C., Tatemichi, T.K., Erkinjuntti, T., Cummings, J.L., Masdeu, J.C., Garcia, J.H., Amaducci, L., Orgogorzo, J.-M., Brun, A., Hofman, A., Moody, D.M., O'Brien, M.D., Yamaguchi, T., Grafman, J., Drayer, B.P., Bennett, D.A., Fisher, M., Ogata, J., Kokmen, E., Bermejo, F., Wolf, P.A., Gorebek, P.B., Bick, K.L., Pajeau, A.K., Bell, M.A., DeCarli, C., Colebras, A., Korczyn, A.D., Bogous-slavsky, J., Hartmann, A., & Scheinberg, P. (1993). Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS-AIREN International Workshop. Neurology, 43, 250–260.CrossRefGoogle ScholarPubMed
Troster, A.I., Butters, N., Salmon, D.P., Cullum, C.M., Jacobs, D., Brandt, J., & White, R.F. (1993). The diagnostic utility of savings scores: Differentiating Alzheimer's and Huntington's diseases with the logical memory and visual reproduction tests. Journal of Clinical and Experimental Neuropsychology, 15(5), 773–788.CrossRefGoogle ScholarPubMed