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Learning and Memory in Adolescents With Critical Biventricular Congenital Heart Disease

Published online by Cambridge University Press:  20 June 2017

Adam R. Cassidy ,
Jane W. Newburger  and
David C. Bellinger
Adam R. Cassidy*
Affiliation:
Department of Psychiatry, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
Jane W. Newburger
Affiliation:
Department of Cardiology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
David C. Bellinger
Affiliation:
Departments of Neurology and Psychiatry, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
*
Correspondence and reprint requests to: Adam R. Cassidy, Center for Neuropsychology, Department of Psychiatry, Boston Children’s Hospital, Boston, MA 02115. E-mail: adam.cassidy@childrens.harvard.edu
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Abstract

Objectives: Although evidence exists of broadly defined memory impairment among adolescents with critical congenital heart disease (CHD), nuanced investigations of declarative memory in this at-risk population have not been conducted. This study had two primary aims: (1) to conduct a fine-grained analysis of a range of relevant learning and memory processes in adolescents with critical biventricular CHD, and (2) to identify risk, odds, and predictors of memory impairment. Methods: Data were combined from two single-center studies of neurodevelopmental outcomes in critical CHD. Two-hundred seven adolescents (M age =15.61±1.0 years) with critical CHD (139 with dextro-transposition of the great arteries and 68 with tetralogy of Fallot without an identified genetic condition), as well as 61 healthy referents (M age =15.27±1.1 years) completed a neuropsychological evaluation which included the Children’s Memory Scale. Results: Whereas visual-spatial memory deficits were found in both CHD subgroups, verbal memory abilities were relatively preserved. Adolescents with CHD demonstrated stronger memory for Stories than Word Pairs, t (203)=2.63, p=.009, and for Dot Locations than Faces, t(204)=−2.57, p=.01. CHD subgroup, socioeconomic status, sex, and seizure history were among the most frequent significant predictors of memory impairment. Seizure history, in particular, was associated with a 2 to 3 times greater odds of impaired performance on learning and memory tasks. Conclusions: Adolescents with critical biventricular CHD are at risk for deficits in aspects of declarative memory. Independent risk factors for worse outcome include history of seizures. (JINS, 2017, 23, 627–639)

Keywords

MemoryRisk factorsCongenital heart defectCardiacAdolescentPediatric
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 23 , Issue 8 , September 2017 , pp. 627 - 639
Copyright
Copyright © The International Neuropsychological Society 2017 

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