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Estrogen and performance in recognition memory for olfactory and visual stimuli in females diagnosed with Alzheimer's disease

Published online by Cambridge University Press:  17 May 2006

ERIN SUNDERMANN ,
PAUL E. GILBERT  and
CLAIRE MURPHY
ERIN SUNDERMANN
Affiliation:
Department of Psychology, San Diego State University, San Diego, California
PAUL E. GILBERT
Affiliation:
Department of Psychology, San Diego State University, San Diego, California Department of Head and Neck Surgery, University of California School of Medicine, San Diego, California
CLAIRE MURPHY
Affiliation:
Department of Psychology, San Diego State University, San Diego, California Department of Head and Neck Surgery, University of California School of Medicine, San Diego, California
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Abstract

Patients with Alzheimer's disease (AD) exhibit a deficit in episodic recognition memory for odors. It is hypothesized that the higher rate of AD in women may be due to estrogen-deprivation in postmenopausal women. Research suggests that estrogen may help to minimize cognitive decline in AD as well as postmenopausal olfactory loss. The current study examined the effects of estrogen replacement therapy (ERT) on performance of a recognition memory task for olfactory and visual stimuli in women AD patients. Participants included 24 women AD patients who were ERT users and 77 women AD patients who never used ERT. Compared with the ERT non-users, the ERT users committed significantly less false-positive memory errors for olfactory stimuli, whereas performance for visual stimuli did not differentiate between ERT users and non-users. The results suggest benefits of ERT could help ameliorate the earliest symptoms of AD, olfactory dysfunction, and memory impairment. (JINS, 2006, 12, 400–404.)

Keywords

OlfactionEstrogen replacement therapyMemory impairmentRecognition memoryAlzheimer's diseaseSmell
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 12 , Issue 3 , May 2006 , pp. 400 - 404
Copyright
© 2006 The International Neuropsychological Society

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References

REFERENCES

Braak, H., Braak, E., Yilmazer, D., de Vos, R., Jansen, E., & Bohl, J. (1996). Pattern of brain destruction in Parkinson's and Alzheimer's diseases. Journal of Neural Transmission, 103, 455–490.CrossRefGoogle Scholar
Clements, J. (1975). Chronology of the United States. New York: McGraw-Hill.
Compton, J., van Amelsvoort, T., & Murphy, D. (2001). HRT and its effect on normal ageing of the brain and dementia. British Journal of Clinical Pharmacology, 52, 647–653.Google Scholar
Davis, K.L., Price, C.C., Kaplan, E., & Libon, D.J. (2002). Error analysis of the nine-word California Verbal Learning Test (CVLT-9) among older adults with and without dementia. Clinical Neuropsychology, 16, 81–89.CrossRefGoogle Scholar
Deems, D.A., Doty, R.L., Settle, G., Moore-Gillon, V., Shaman, P., Mester, A.F., Kimmelman, C.P., Brightman, V.J., & Snow, J.B., Jr. (1991). Smell and taste disorders: A study of 750 patients from the University of Pennsylvania Smell and Taste Center. Archives of Otolaryngology-Head and Neck Surgery, 117, 519–528.CrossRefGoogle Scholar
Gibbs, R.B. (1998). Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement. Brain Research, 787, 259–268.CrossRefGoogle Scholar
Gilbert, P.E. & Murphy, C. (2004a). Differences between recognition memory and remote memory for olfactory and visual stimuli in nondemented elderly individuals genetically at risk for Alzheimer's disease. Experimental Gerontology, 39, 433–441.Google Scholar
Gilbert, P.E. & Murphy, C. (2004b). The effect of the ApoE epsilon4 allele on recognition memory for olfactory and visual stimuli in patients with pathologically confirmed Alzheimer's disease, probable Alzheimer's disease, and healthy elderly controls. Journal of Clinical and Experimental Neuropsychology, 26, 779–794.Google Scholar
Gould, E., Woolley, C.S., Frankfurt, M., & McEwen, B.S. (1990). Gonadal Steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. The Journal of Neuroscience, 10, 1286–1290.Google Scholar
Macmillan, N.A. & Creelman, D.C. (1991). Signal detection theory: A user's guide. New York: Cambridge University Press.
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., & Stadan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology, 34, 939–944.CrossRefGoogle Scholar
Murphy, C., Cain, W.S., Gilmore, M.M., & Skinner, R.B. (1991). Sensory and semantic factors in recognition memory for odors and graphic stimuli: Elderly versus young persons. American Journal of Psychology, 104, 161–192.CrossRefGoogle Scholar
Murphy, C., Gilmore, M.M., Seery, C.S., Salmon, D.P., & Lasker, B.R. (1990). Olfactory thresholds are associated with degree of dementia in Alzheimer's disease, Neurobiology of Aging, 11, 465–469.Google Scholar
Murphy, C., Schubert, C.R., Cruickshanks, K.J., Klein, B.E.K., Klein, R., & Nondahl, D.M. (2002). Prevalence of olfactory impairment in older adults. Journal of the American Medical Association, 288, 2307–2312.CrossRefGoogle Scholar
Nordin, S. & Murphy, C. (1998). Odor memory in normal aging and Alzheimer's disease. Annals of the New York Academy of Sciences, 855, 686–693.CrossRefGoogle Scholar
Ohkura, T., Isse, K., Akazawa, K., Hamamoto, M., Yaoi, Y., & Hagino, N. (1995). Long-term estrogen replacement therapy in female patients with dementia of the Alzheimer type: Seven case reports. Dementia, 6, 99–107.Google Scholar
Osterlund, M. & Hurd, Y. (2001). Estrogen receptors in the human forebrain and the Relation to neuropsychiatric disorders. Progress in Neurobiology, 64, 251–267.CrossRefGoogle Scholar
Price, J., Davis, P., Morris, J., & White, D. (1991). The distribution of tangles, plaques and related immunohistochemical markers in early aging and Alzheimer's disease. Neurobiology of Aging, 12, 295–312.CrossRefGoogle Scholar
Shumaker, S.A., Legault, C., & Rapp, S.R. (2003). Estrogen plus progestin and the incidence of probable dementia and mild cognitive impairment in postmenopausal women: The Women's Health Initiative Memory Study: A randomized controlled trial. Journal of the American Medical Association, 289, 2651–2662.CrossRefGoogle Scholar
Srivastava, R.K., Bhasin, N., & Srivastava, N. (1996). Apolipoprotein ε gene expression in various tissues of mouse and regulation by estrogen. Biochemistry and Molecular Biology International, 38, 91–101.Google Scholar
Thal, L.J., Thomas, R.G., Mulnard, R., Sano, M., Grundman, M., & Schneider, L. (2003). Estrogen levels do not correlate with improvement in cognition. Archives of Neurology, 60, 209–212.CrossRefGoogle Scholar
Van Hoesen, G.W. & Solodkin, A. (1994). Cellular and systems neuroanantomical changes in Alzheimer's disease. Annals of the New York Academy of Sciences, 747, 12–35.Google Scholar