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A Meta-Analysis of Neuropsychological Functioning in the Logopenic Variant of Primary Progressive Aphasia: Comparison with the Semantic and Non-Fluent Variants

Published online by Cambridge University Press:  29 October 2019

Vidyulata Kamath Open the ORCID record for Vidyulata Kamath [Opens in a new window] ,
Emily R. Sutherland  and
Grace-Anna Chaney
Vidyulata Kamath*
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USA
Emily R. Sutherland
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USA
Grace-Anna Chaney
Affiliation:
Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD21205, USA
*
*Correspondence and reprint requests to: Vidyulata Kamath, 600 N. Wolfe Street, Meyer 218, Baltimore, MD 21287-7218, USA. E-mail: vkamath@jhmi.edu
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Abstract

Objectives:

The logopenic variant of primary progressive aphasia (lvPPA) has disparate pathological and anatomical features when compared to the semantic (svPPA) and non-fluent (nfvPPA) variants of PPA. As such, there is increasing need for measures that improve diagnostic accuracy particularly when etiology-specific treatments become available. In the current study, we used meta-analytic methods to establish the neuropsychological profile of lvPPA and compare it to recent findings in svPPA and nfvPPA.

Methods:

We extracted neuropsychological data from 51 publications representing 663 lvPPA patients and 1379 controls. We calculated Hedges’ g effect sizes for nine domains of neuropsychological functioning in lvPPA and assessed the influence of demographic, disease, and task characteristics on effect size magnitude. Results obtained in lvPPA were compared to findings in svPPA and nfvPPA.

Results:

In lvPPA, the magnitude of deficits in attention, math, visuospatial memory, and executive functioning were as prominent as language deficits. Within the language domain, lvPPA patients demonstrated greater naming than repetition deficits. Compared to svPPA and nfvPPA, lvPPA patients demonstrated greater neuropsychological deficits overall and greater impairment on attention, math, and visual set-shifting tests.

Conclusions:

Tests of attention, delayed visuospatial memory, visual set-shifting, and math distinguish lvPPA from svPPA and nfvPPA likely reflecting the posterior temporoparietal atrophy observed early in the course of lvPPA. These findings support the inclusion of these measures in the clinical neuropsychological assessment of lvPPA and underscore the need for additional clinicopathological and longitudinal studies of arithmetic and visuospatial memory across the PPA variants.

Keywords

CognitionAlzheimer’s diseaseLogopenic aphasiaPrimary progressive aphasiaMemoryNeuropsychological
Type
Critical Review
Information
Journal of the International Neuropsychological Society , Volume 26 , Issue 3 , March 2020 , pp. 322 - 330
Copyright
Copyright © INS. Published by Cambridge University Press, 2019

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