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Neural Correlates of Cognitive Fatigue: Cortico-Striatal Circuitry and Effort–Reward Imbalance

Published online by Cambridge University Press:  10 July 2013

Ekaterina Dobryakova ,
John DeLuca ,
Helen M. Genova  and
Glenn R. Wylie
Ekaterina Dobryakova*
Affiliation:
Kessler Foundation Research Center, West Orange, New Jersey Rutgers University, Biomedical and Health Sciences, Newark, New Jersey
John DeLuca
Affiliation:
Kessler Foundation Research Center, West Orange, New Jersey Rutgers University, Biomedical and Health Sciences, Newark, New Jersey
Helen M. Genova
Affiliation:
Kessler Foundation Research Center, West Orange, New Jersey Rutgers University, Biomedical and Health Sciences, Newark, New Jersey
Glenn R. Wylie
Affiliation:
Kessler Foundation Research Center, West Orange, New Jersey Rutgers University, Biomedical and Health Sciences, Newark, New Jersey War Related Illness & Injury Study Center, Department of Veteran's Affairs, East Orange, New Jersey
*
Correspondence and reprint requests to: Ekaterina Dobryakova, Kessler Foundation Research Center, 300 Executive Drive, Suite 70, West Orange, NJ, USA. E-mail: edobryakova@kesslerfoundation.org
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Abstract

Recently, there has been renewed interest in the study of cognitive fatigue. It is known that fatigue is one of the most disabling symptoms in numerous neurological populations, including stroke, multiple sclerosis, Parkinson's disease, and traumatic brain injury. Behavioral studies of cognitive fatigue are hampered by lack of correlation of self-report measures with objective performance. Neuroimaging studies provide new insight about cognitive fatigue and its neural correlates. Impairment within the cortico-striatal network, involved in effort–reward calculation, has been suggested to be critically related to fatigue. The current review surveys the recent neuroimaging literature, and suggests promising avenues for future research. (JINS, 2013, 19, 1–5)

Keywords

Cognitive fatigueBasal gangliaReward networkEffort-reward relationshipMRI
Type
Short Review
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 8 , September 2013 , pp. 849 - 853
Copyright
Copyright © The International Neuropsychological Society 2013 

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