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Physical Activity Associated with Increased Resting-State Functional Connectivity in Multiple Sclerosis

Published online by Cambridge University Press:  11 October 2011

Ruchika Shaurya Prakash ,
Beth Patterson ,
Alisha Janssen ,
Amir Abduljalil  and
Aaron Boster
Ruchika Shaurya Prakash*
Affiliation:
Department of Psychology, The Ohio State University, Columbus, Ohio
Beth Patterson
Affiliation:
Department of Psychology, The Ohio State University, Columbus, Ohio
Alisha Janssen
Affiliation:
Department of Psychology, The Ohio State University, Columbus, Ohio
Amir Abduljalil
Affiliation:
Department of Radiology, The Ohio State University, Columbus, Ohio
Aaron Boster
Affiliation:
Department of Neurology, The Ohio State University, Columbus, Ohio
*
Correspondence and reprint requests to: Ruchika Shaurya Prakash, Department of Psychology, The Ohio State University, 1835 Neil Avenue, Columbus, OH 43210. E-mail: prakash.30@osu.edu
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Abstract

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, resulting in physical, cognitive and affective disturbances, with notable declines in the ability to learn and retain new information. In this study, we examined if higher levels of physical activity in MS individuals were associated with an increased resting-state connectivity of the hippocampus and cortex, resulting in better performance on a task of episodic memory. Forty-five individuals with a clinically definite diagnosis of MS were recruited for the study. Consistent with previous reports, hippocampus was functionally connected to the posteromedial cortex, parahippocampal gyrus, superior frontal gyrus, and the medial frontal cortex. Higher levels of physical activity in MS patients were associated with an increased coherence between the hippocampus and the posteromedial cortex (PMC). The increased connectivity between these two regions, in turn, was predictive of better relational memory, such that MS patients who showed an increased coherence between the left (not right) hippocampus and the PMC also showed better relational memory. Results of the study are interpreted in light of the challenge of disentangling effects of physical activity from effects of disease severity and its neuropathological correlates. (JINS, 2011, 17, 986–997)

Keywords

HippocampusResting-state functional connectivityEpisodic memoryMultiple sclerosisPosteromedial cortex.
Type
Symposium
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 6 , November 2011 , pp. 986 - 997
Copyright
Copyright © The International Neuropsychological Society 2011

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