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REM Sleep Behavior Disorder in Parkinson’s Disease: Effects on Cognitive, Psychiatric, and Functional outcomes

Published online by Cambridge University Press:  07 May 2020

Zanjbeel Mahmood Open the ORCID record for Zanjbeel Mahmood [Opens in a new window] ,
Ryan Van Patten ,
Marina Z. Nakhla ,
Elizabeth W. Twamley ,
J. Vincent Filoteo  and
Dawn M. Schiehser
Zanjbeel Mahmood
Affiliation:
SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Ct, San Diego, CA, USA Research Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA
Ryan Van Patten
Affiliation:
Research Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA92093, USA
Marina Z. Nakhla
Affiliation:
SDSU/UC San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Ct, San Diego, CA, USA Research Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA
Elizabeth W. Twamley
Affiliation:
Research Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA92093, USA Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA
J. Vincent Filoteo
Affiliation:
Research Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA92093, USA Department of Neurosciences, Movement Disorders Center, University of California, San Diego, CA, USA
Dawn M. Schiehser*
Affiliation:
Research Service, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA Department of Psychiatry, University of California San Diego, 9500 Gilman Dr, La Jolla, CA92093, USA Center of Excellence for Stress and Mental Health, VA San Diego Healthcare System, 3350 La Jolla Village Dr., San Diego, CA92161, USA
*
*Corresponding Author: Dawn Schiehser, PhD, Research Service, VA San Diego Healthcare System, MC 151-B, La Jolla, CA92161, Email: dschiehser@ucsd.edu. Phone: +858-552-8585 ext. 2664
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Abstract

Objective:

Rapid eye movement sleep behavior disorder (RBD) affects 33–46% of patients with Parkinson’s disease (PD) and may be a risk factor for neuropsychological and functional deficits. However, the role of RBD on neuropsychological functioning in PD has yet to be fully determined. We, therefore, examined differences in neurocognitive performance, functional capacity, and psychiatric symptoms among nondemented PD patients with probable RBD (PD/pRBD+) and without (PD/pRBD−), and healthy comparison participants (HC).

Methods:

Totally, 172 participants (58 PD/pRBD+; 65 PD/pRBD−; 49 HC) completed an RBD sleep questionnaire, psychiatric/clinical questionnaires, performance-based and self-reported functional capacity measures, and underwent a comprehensive neuropsychological battery assessing attention/working memory, language, visuospatial function, verbal and visual learning and memory, and executive function.

Results:

Controlling for psychiatric symptom severity, the PD/pRBD+ group had poorer executive functioning and learning performance than the PD/pRBD− group and poorer neuropsychological functioning across all individual cognitive domains than the HCs. In contrast, PD/pRBD− patients had significantly lower scores than HCs only in the language domain. Moreover, PD/pRBD+ patients demonstrated significantly poorer medication management skills compared to HCs. Both PD groups reported greater depressive and anxiety severity compared to HCs; PD/pRBD+ group also endorsed greater severity of apathy compared to HCs.

Conclusions:

The presence of pRBD is associated with poorer neuropsychological functioning in PD such that PD patients with pRBD have poorer cognitive, functional, and emotional outcomes compared to HC participants and/or PD patients without pRBD. Our findings underscore the importance of RBD assessment for improved detection and treatment of neuropsychological deficits (e.g., targeted cognitive interventions).

Keywords

Executive functioningLearningNeuropsychologyFunctional capacityApathyCognition
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 26 , Issue 9 , October 2020 , pp. 894 - 905
Copyright
Copyright © INS. Published by Cambridge University Press, 2020

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References

REFERENCES

Aarsland, D., Creese, B., Politis, M., Chaudhuri, K.R., Ffytche, D.H., Weintraub, D., & Ballard, C. (2017). Cognitive decline in Parkinson disease. Nature Reviews Neurology, 13(4), 217–231. doi: 10.1038/nrneurol.2017.27CrossRefGoogle ScholarPubMed
Aarsland, D., Marsh, L., & Schrag, A. (2009). Neuropsychiatric symptoms in Parkinson’s disease. Movement Disorders, 24(15), 2175–2186. doi: 10.1002/mds.22589CrossRefGoogle ScholarPubMed
Anang, J.B.M., Gagnon, J.F., Bertrand, J.A., Romenets, S.R., Latreille, V., Panisset, M., … Postuma, R.B. (2014). Predictors of dementia in Parkinson disease: A prospective cohort study. Neurology, 83(14), 1253–1260. doi: 10.1212/WNL.0000000000000842CrossRefGoogle ScholarPubMed
Ansari, M., Rahmani, F., Dolatshahi, M., Pooyan, A., & Aarabi, M.H. (2017). Brain pathway differences between Parkinson’s disease patients with and without REM sleep behavior disorder. Sleep and Breathing, 21(1), 155–161. doi: 10.1007/s11325-016-1435-8CrossRefGoogle ScholarPubMed
Barnes, L.L.B., Harp, D., & Jung, W.S. (2002). Reliability generalization of scores on the Spielberger State-Trait Anxiety Inventory. Educational and Psychological Measurement, 62(4), 603–618. doi: 10.1177/0013164402062004005CrossRefGoogle Scholar
Berg, D., Postuma, R.B., Adler, C.H., Bloem, B.R., Chan, P., Dubois, B., … Deuschl, G. (2015). MDS research criteria for prodromal Parkinson’s disease. Movement Disorders, 30(12), 1600–1611. doi: 10.1002/mds.26431CrossRefGoogle ScholarPubMed
Berg, D., Postuma, R.B., Bloem, B., Chan, P., Dubois, B., Gasser, T., … Lang, A.E. (2014). Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson’s disease. Movement Disorders, 29(4), 454–462. doi: 10.1002/mds.25844CrossRefGoogle ScholarPubMed
Boeve, B.F., Molano, J.R., Ferman, T.J., Smith, G.E., Lin, S.C., Bieniek, K., … Lucas, J.A. (2011). Validation of the Mayo Sleep Questionnaire to screen for REM sleep behavior disorder in an aging and dementia cohort. Sleep medicine, 12(5), 445–453.10.1016/j.sleep.2010.12.009CrossRefGoogle Scholar
Borek, L.L., Kohn, R., & Friedman, J.H. (2006). Mood and sleep in Parkinson’s disease. The Journal of Clinical Psychiatry, 67(6), 958–963.CrossRefGoogle ScholarPubMed
Bugalho, P. & Paiva, T. (2011). Dream features in the early stages of Parkinson’s Disease. Journal of Neural Transmission, 118(11), 1613. doi: 10.1007/s00702-011-0679-5CrossRefGoogle ScholarPubMed
Chahine, L.M., Amara, A.W., & Videnovic, A. (2017). A systematic review of the literature on disorders of sleep and wakefulness in Parkinson’s disease from 2005 to 2015. Sleep Medicine Reviews, 35, 33–50. doi: 10.1016/j.smrv.2016.08.001CrossRefGoogle ScholarPubMed
Chahine, L.M., Weintraub, D., Hawkins, K.A., Siderowf, A., Eberly, S., Oakes, D., … PARS Investigators. (2016). Cognition in individuals at risk for Parkinson’s: Parkinson associated risk syndrome (PARS) study findings. Movement Disorders, 31(1), 86–94. doi: 10.1002/mds.26373CrossRefGoogle ScholarPubMed
Chaudhuri, K.R., Healy, D.G., & Schapira, A.H.V. (2006). Non-motor symptoms of Parkinson’s disease: Diagnosis and management. The Lancet Neurology, 5(3), 235–245. doi: 10.1016/S1474-4422(06)70373-8CrossRefGoogle ScholarPubMed
Daley, D.J., Myint, P.K., Gray, R.J., & Deane, K.H.O.L. (2012). Systematic review on factors associated with medication non-adherence in Parkinson’s disease. Parkinsonism and Related Disorders, 18(10), 1053–1061. doi: 10.1016/j.parkreldis.2012.09.004CrossRefGoogle ScholarPubMed
Delis, D., Kaplan, E., & Kramer, J. (2001). Delis-Kaplan Executive Function System (D-KEFS): Examiner’s manual. San Antonio, TX: The Psychological Corporation.Google Scholar
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B.A. (2000). CVLT-II: California Verbal Learning Test: Adult Version. San Antonio, TX: The Psychological Corporation.Google Scholar
den Brok, M.G.H.E., van Dalen, J.W., van Gool, W.A., Moll van Charante, E.P., de Bie, R.M.A., & Richard, E. (2015). Apathy in Parkinson’s disease: A systematic review and meta-analysis. Movement Disorders, 30(6), 759–769. doi: 10.1002/mds.26208CrossRefGoogle ScholarPubMed
Dirnberger, G. & Jahanshahi, M. (2013). Executive dysfunction in Parkinson’s disease: A review. Journal of Neuropsychology, 7(2), 193–224. doi: 10.1111/jnp.12028CrossRefGoogle ScholarPubMed
Dissanayaka, N.N.W., Lawson, R.A., Yarnall, A.J., Duncan, G.W., Breen, D.P., Khoo, T.K., … Burn, D.J. (2017). Anxiety is associated with cognitive impairment in newly-diagnosed Parkinson’s disease. Parkinsonism and Related Disorders, 36, 63–68. doi: 10.1016/j.parkreldis.2017.01.001CrossRefGoogle ScholarPubMed
Emre, M., Aarsland, D., Brown, R., Burn, D.J., Duyckaerts, C., Mizuno, Y., … Dubois, B. (2007). Clinical diagnostic criteria for dementia associated with Parkinson’s disease. Movement Disorders, 22(12), 1689–1707. doi: 10.1002/mds.21507CrossRefGoogle ScholarPubMed
Erro, R., Santangelo, G., Picillo, M., Vitale, C., Amboni, M., Longo, K., … Barone, P. (2012). Link between non-motor symptoms and cognitive dysfunctions in de novo, drug-naive PD patients. Journal of Neurology, 259(9), 1808–1813. doi: 10.1007/s00415-011-6407-0CrossRefGoogle ScholarPubMed
Fereshtehnejad, S.M., Romenets, S.R., Anang, J.B.M., Latreille, V., Gagnon, J.F., & Postuma, R.B. (2015). New clinical subtypes of Parkinson disease and their longitudinal progression a prospective cohort comparison with other phenotypes. JAMA Neurology, 72(8), 863–873. doi: 10.1001/jamaneurol.2015.0703CrossRefGoogle ScholarPubMed
Ferini–Strambi, L., Di Gioia, M.R., Castronovo, V., Oldani, A., Zucconi, M., & Cappa, S.F. (2004). Neuropsychological assessment in idiopathic REM sleep behavior disorder (RBD): Does the idiopathic form of RBD really exist?. Neurology, 62(1), 41–45. doi: 10.1212/01.WNL.0000101726.69701.FACrossRefGoogle ScholarPubMed
Ford, A.H., Duncan, G.W., Firbank, M.J., Yarnall, A.J., Khoo, T.K., Burn, D.J., & O’Brien, J.T. (2013). Rapid eye movement sleep behavior disorder in Parkinson’s disease: Magnetic resonance imaging study. Movement Disorders, 28(6), 832–836. doi: 10.1002/mds.25367CrossRefGoogle ScholarPubMed
Gagnon, J.-F., Bédard, M.-A., Fantini, M.L., Petit, D., Panisset, M., Rompré, S., … Montplaisir, J. (2002). REM sleep behavior disorder and REM sleep without atonia in Parkinson’s disease. Neurology, 59(4), 585LP–589. doi: 10.1212/WNL.59.4.585CrossRefGoogle ScholarPubMed
Gagnon, J.F., Fantini, M.L., Bédard, M.A., Petit, D., Carrier, J., Rompré, S., … Montplaisir, J. (2004). Association between waking EEG slowing and REM sleep behavior disorder in PD without dementia. Neurology, 62(3), 401–406. doi: 10.1212/01.WNL.0000106460.34682.E9CrossRefGoogle ScholarPubMed
Gagnon, J.-F., Vendette, M., Postuma, R.B., Desjardins, C., Massicotte-Marquez, J., Panisset, M., & Montplaisir, J. (2009). Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson’s disease. Annals of Neurology, 66(1), 39–47. doi: 10.1002/ana.21680CrossRefGoogle ScholarPubMed
Génier Marchand, D., Postuma, R.B., Escudier, F., De Roy, J., Pelletier, A., Montplaisir, J., & Gagnon, J. (2018). How does dementia with Lewy bodies start? prodromal cognitive changes in REM sleep behavior disorder. Annals of Neurology, 83(5), 1016–1026. doi: 10.1002/ana.25239CrossRefGoogle ScholarPubMed
Goetz, C.G., Poewe, W., Rascol, O., Sampaio, C., Stebbins, G.T., Counsell, C., y Seidl, L. (2004). Movement Disorder Society Task Force Report on the Hoehn and Yahr Staging Scale: Status and recommendations. Movement Disorders, 19(9), 1020–1028. https://doi-org.libproxy.sdsu.edu/10.1002/mds.20213CrossRefGoogle ScholarPubMed
Goetz, C.G., Tilley, B.C., Shaftman, S.R., Stebbins, G.T., Fahn, S., Martinez-Martin, P., … LaPelle, N. (2008). Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders: Official Journal of the Movement Disorder Society, 23(15), 2129–2170. doi: 10.1002/mds.22340CrossRefGoogle ScholarPubMed
Goldman, J.G., Holden, S.K., Litvan, I., McKeith, I., Stebbins, G.T., & Taylor, J.P. (2018). Evolution of diagnostic criteria and assessments for Parkinson’s disease mild cognitive impairment. Movement Disorders, 33(4), 503–510. doi: 10.1002/mds.27323CrossRefGoogle ScholarPubMed
Gong, Y., Xiong, K., Mao, C., Shen, Y., Hu, W., Huang, J., … Liu, C. (2014). Clinical manifestations of Parkinson disease and the onset of rapid eye movement sleep behavior disorder. Sleep Medicine, 15(6), 647–653. doi: doi: 10.1016/j.sleep.2013.12.021CrossRefGoogle ScholarPubMed
Grosset, K.A., Bone, I., & Grosset, D.G. (2005). Suboptimal medication adherence in Parkinson’s disease. Movement Disorders, 20(11), 1502–1507. doi: 10.1002/mds.20602CrossRefGoogle ScholarPubMed
Heaton, R.K., Chelune, G.J., Talley, J.L., Kay, G.G., & Curtiss, G. (1993). Wisconsin Card Sorting Test Manual: Revised and Extended. Odessa, FL: Psychological Assessment Resources.Google Scholar
Hu, M.T.M., Szewczyk-Królikowski, K., Tomlinson, P., Nithi, K., Rolinski, M., Murray, C., … Ben-Shlomo, Y. (2014). Predictors of cognitive impairment in an early stage Parkinson’s disease cohort. Movement Disorders, 29(3), 351–359. doi: 10.1002/mds.25748CrossRefGoogle Scholar
Hughes, A.J., Ben-Shlomo, Y., Daniel, S.E., & Lees, A.J. (1992). What features improve the accuracy of clinical diagnosis in Parkinson’s disease: A clinicopathologic study. Neurology, 42(6), 1142 LP–1142. doi: 10.1212/WNL.42.6.1142CrossRefGoogle ScholarPubMed
Jozwiak, N., Montplaisir, J., Latreille, V., Bourgouin, P.-A., Gagnon, J.-F., Postuma, R.B., … Chouinard, S. (2017). REM Sleep Behavior Disorder and cognitive impairment in Parkinson’s disease. Sleep, 40(8). doi: 10.1093/sleep/zsx101CrossRefGoogle ScholarPubMed
Kehagia, A.A., Barker, R.A., & Robbins, T.W. (2010). Neuropsychological and clinical heterogeneity of cognitive impairment and dementia in patients with Parkinson’s disease. The Lancet Neurology, 9(12), 1200–1213. doi: doi: 10.1016/S1474-4422(10)70212-XCrossRefGoogle ScholarPubMed
Kudlicka, A., Clare, L., & Hindle, J.V. (2011). Executive functions in Parkinson’s disease: Systematic review and meta-analysis. Movement Disorders, 26(13), 2305–2315. doi: 10.1002/mds.23868CrossRefGoogle ScholarPubMed
Kulkarni, A.S., Balkrishnan, R., Anderson, R.T., Edin, H.M., Kirsch, J., & Stacy, M.A. (2008). Medication adherence and associated outcomes in medicare health maintenance organization-enrolled older adults with Parkinson’s disease. Movement Disorders, 23(3), 359–365. doi: 10.1002/mds.21831CrossRefGoogle ScholarPubMed
Lavault, S., Leu-Semenescu, S., du Montcel, S., de Cock, V., Vidailhet, M., & Arnulf, I. (2010). Does clinical rapid eye movement behavior disorder predict worse outcomes in Parkinson’s disease? Journal of Neurology, 257(7), 1154–1159. doi: 10.1007/s00415-010-5482-yCrossRefGoogle ScholarPubMed
Lawton, M.P. & Brody, E.M. (1969). Assessment of older people: Self-maintaining and instrumental activities of daily living. The Gerontologist, 9(3_Part_1), 179–186. doi: 10.1093/geront/9.3_Part_1.179CrossRefGoogle ScholarPubMed
Lawson, R.A., Yarnall, A.J., Duncan, G.W., Breen, D.P., Khoo, T.K., Williams-Gray, C.H., … Study Group, ICICLE-PD (2016). Cognitive decline and quality of life in incident Parkinson’s disease: The role of attention. Parkinsonism and Related Disorders, 27, 47–53. doi: 10.1016/j.parkreldis.2016.04.009CrossRefGoogle ScholarPubMed
Leentjens, A.F.G., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I.H., Starkstein, S.E., … Goetz, C.G. (2008a). Anxiety rating scales in Parkinson’s disease: Critique and recommendations. Movement Disorders, 23(14), 2015–2025. doi: 10.1002/mds.22233CrossRefGoogle ScholarPubMed
Leentjens, A.F.G., Dujardin, K., Marsh, L., Martinez-Martin, P., Richard, I.H., Starkstein, S.E., … Goetz, C.G. (2008b). Apathy and anhedonia rating scales in Parkinson’s disease: Critique and recommendations. Movement Disorders, 23(14), 2004–2014. doi: 10.1002/mds.22229CrossRefGoogle ScholarPubMed
Leopold, N.A., Polansky, M., & Hurka, M.R. (2004). Drug adherence in Parkinson’s disease. Movement Disorders, 19(5), 513–517. doi: 10.1002/mds.20041CrossRefGoogle ScholarPubMed
Lim, J.S., Shin, S.A., Lee, J.Y., Nam, H., Lee, J.Y., & Kim, Y.K. (2016). Neural substrates of rapid eye movement sleep behavior disorder in Parkinson’s disease. Parkinsonism and Related Disorders, 23, 31–36. doi: 10.1016/j.parkreldis.2015.11.027CrossRefGoogle ScholarPubMed
Litvan, I., Goldman, J.G., Tröster, A.I., Schmand, B.A., Weintraub, D., Petersen, R.C., … & Aarsland, D. (2012). Diagnostic criteria for mild cognitive impairment in Parkinson’s disease: Movement Disorder Society Task Force guidelines. Movement Disorders, 27(3), 349–356. doi: 10.1002/mds.24893CrossRefGoogle ScholarPubMed
Llebaria, G., Pagonabarraga, J., Kulisevsky, J., García-Sánchez, C., Pascual-Sedano, B., Gironell, A., & Martínez-Corral, M. (2008). Cut-off score of the Mattis Dementia Rating Scale for screening dementia in Parkinson’s disease. Movement Disorders, 23(11), 1546–1550. doi: 10.1002/mds.22173CrossRefGoogle ScholarPubMed
Marques, A., Dujardin, K., Boucart, M., Pins, D., Delliaux, M., Defebvre, L., … Monaca, C. (2010). REM sleep behaviour disorder and visuoperceptive dysfunction: A disorder of the ventral visual stream? Journal of Neurology, 257(3), 383–391. doi: 10.1007/s00415-009-5328-7CrossRefGoogle ScholarPubMed
Nomura, T., Inoue, Y., Kagimura, T., Uemura, Y., & Nakashima, K. (2011). Utility of the REM sleep behavior disorder screening questionnaire (RBDSQ) in Parkinson’s disease patients. Sleep Medicine, 12(7), 711–713. doi: 10.1016/j.sleep.2011.01.015CrossRefGoogle Scholar
Nomura, T., Inoue, Y., Kagimura, T., & Nakashima, K. (2013). Clinical significance of REM sleep behavior disorder in Parkinson’s disease. Sleep Medicine, 14(2), 131–135. doi: 10.1016/j.sleep.2012.10.011CrossRefGoogle ScholarPubMed
Oguru, M., Tachibana, H., Toda, K., Okuda, B., & Oka, N. (2010). Apathy and depression in Parkinson disease. Journal of Geriatric Psychiatry and Neurology, 23(1), 35–41. doi: 10.1177/0891988709351834CrossRefGoogle ScholarPubMed
Patterson, T.L., Goldman, S., McKibbin, C.L., Hughs, T., & Jeste, D.V. (2001). UCSD Performance-Based Skills Assessment: Development of a new measure of everyday functioning for severely mentally ill adults. Schizophrenia Bulletin, 27(2), 235–245. doi: 10.1093/oxfordjournals.schbul.a006870CrossRefGoogle ScholarPubMed
Patterson, T.L., Lacro, J., McKibbin, C.L., Moscona, S., Hughs, T., & Jeste, D.V. (2002). Medication Management Ability Assessment: Results from a performance-based measure in older outpatients with schizophrenia. Journal of Clinical Psychopharmacology, 22(1), 11–19.10.1097/00004714-200202000-00003CrossRefGoogle ScholarPubMed
Pedersen, K.F., Larsen, J.P., Tysnes, O.-B., & Alves, G. (2017). Natural course of mild cognitive impairment in Parkinson disease: A 5-year population-based study. Neurology, 88(8), 767–774. doi: 10.1212/WNL.0000000000003634CrossRefGoogle ScholarPubMed
Pirogovsky-Turk, E., Moore, R.C., Filoteo, J.V., Litvan, I., Song, D.D., Lessig, S.L., & Schiehser, D.M. (2017). Neuropsychiatric predictors of cognitive decline in Parkinson disease: A longitudinal study. American Journal of Geriatric Psychiatry, 25(3), 279–289. doi: 10.1016/j.jagp.2016.10.004CrossRefGoogle ScholarPubMed
Pirogovsky-Turk, E., Schiehser, D.M., Obtera, K.M., Burke, M.M., Lessig, S.L., Song, D.D., … Filoteo, J.V. (2014). Instrumental activities of daily living are impaired in Parkinson’s disease patients with mild cognitive impairment. Neuropsychology, Vol. 28, pp. 229–237. doi: 10.1037/neu0000045CrossRefGoogle Scholar
Plomhause, L., Dujardin, K., Duhamel, A., Delliaux, M., Derambure, P., Defebvre, L., & Monaca Charley, C. (2013). Rapid eye movement sleep behavior disorder in treatment-naïve Parkinson disease patients. Sleep Medicine, 14(10), 1035–1037. doi: doi: 10.1016/j.sleep.2013.04.018CrossRefGoogle ScholarPubMed
Poewe, W. (2008). Non-motor symptoms in Parkinson’s disease. European Journal of Neurology, 15(s1), 14–20. doi: 10.1111/j.1468-1331.2008.02056.xCrossRefGoogle ScholarPubMed
Postuma, R.B., Berg, D., Stern, M., Poewe, W., Olanow, C.W., Oertel, W., … Deuschl, G. (2015). MDS clinical diagnostic criteria for Parkinson’s disease. Movement Disorders: Official Journal of the Movement Disorder Society, 30(12), 1591–1601. doi: 10.1002/mds.26424CrossRefGoogle ScholarPubMed
Postuma, R.B., Iranzo, A., Hu, M., Högl, B., Boeve, B.F., Manni, R., … Puligheddu, M. (2019). Risk and predictors of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: A multicentre study. Brain, 142(3), 744–759. doi: 10.1093/brain/awz030CrossRefGoogle ScholarPubMed
Postuma, R.B., Gagnon, J.-F., Vendette, M., Charland, K., & Montplaisir, J. (2008). Manifestations of Parkinson disease differ in association with REM sleep behavior disorder. Movement Disorders, 23(12), 1665–1672. doi: 10.1002/mds.22099CrossRefGoogle ScholarPubMed
Postuma, R.B., Lang, A.E., Gagnon, J.F., Pelletier, A., & Montplaisir, J.Y. (2012). How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder. Brain, 135(6), 1860–1870. doi: 10.1093/brain/aws093CrossRefGoogle ScholarPubMed
Riedel, O., Klotsche, J., Spottke, A., Deuschl, G., Förstl, H., Henn, F., … Wittchen, H.-U. (2008). Cognitive impairment in 873 patients with idiopathic Parkinson’s disease. Journal of Neurology, 255(2), 255–264. doi: 10.1007/s00415-008-0720-2CrossRefGoogle ScholarPubMed
Rolinski, M., Szewczyk-Krolikowski, K., Tomlinson, P.R., Nithi, K., Talbot, K., Ben-Shlomo, Y., & Hu, M.T.M. (2014). REM sleep behaviour disorder is associated with worse quality of life and other non-motor features in early Parkinson’s disease. Journal of Neurology, Neurosurgery and Psychiatry, 85(5), 560–566. doi: 10.1136/jnnp-2013-306104CrossRefGoogle ScholarPubMed
Schapira, A.H.V, Chaudhuri, K.R., & Jenner, P. (2017). Non-motor features of Parkinson disease. Nature Reviews Neuroscience, 18(7), 435. doi: 10.1038/nrn.2017.62CrossRefGoogle ScholarPubMed
Schiehser, D.M., Han, S.D., Lessig, S., Song, D.D., Zizak, V., & Filoteo, J.V. (2009). Predictors of health status in nondepressed and nondemented individuals with Parkinson’s disease. Archives of Clinical Neuropsychology, 24(7), 699–709. doi: 10.1093/arclin/acp064CrossRefGoogle ScholarPubMed
Schmidt, R., Freidl, W., Fazekas, F., Reinhart, B., Grieshofer, P., Koch, M., … Lechner, H. (1994). The Mattis Dementia Rating Scale: Normative data from 1,001 healthy volunteers. Neurology, 44(5), 964–964. doi: 10.1212/WNL.44.5.964CrossRefGoogle ScholarPubMed
Sinforiani, E., Zangaglia, R., Manni, R., Cristina, S., Marchioni, E., Nappi, G., … Pacchetti, C. (2006). REM sleep behavior disorder, hallucinations, and cognitive impairment in Parkinson’s disease. Movement Disorders, 21(4), 462–466. doi: 10.1002/mds.20719CrossRefGoogle ScholarPubMed
Sixel-Döring, F., Trautmann, E., Mollenhauer, B., & Trenkwalder, C. (2011). Associated factors for REM sleep behavior disorder in Parkinson disease. Neurology, 77(11), 1048 LP–1054. doi: 10.1212/WNL.0b013e31822e560eCrossRefGoogle ScholarPubMed
Sixel-Döring, F., Trautmann, E., Mollenhauer, B., & Trenkwalder, C. (2014). Rapid Eye Movement Sleep behavioral events: A new marker for neurodegeneration in early Parkinson disease? Sleep, 37(3), 431–438. doi: 10.5665/sleep.3468CrossRefGoogle ScholarPubMed
Spielberger, C.D., Gorsuch, R.L., Lushene, R., Vagg, P.R., & Jacobs, G.A. (1983). Manual for the State-Trait Anxiety Inventory. Palo Alto, CA: Consulting Psychologists Press.Google Scholar
Starkstein, S.E., Mayberg, H.S., Preziosi, T., Andrezejewski, P., Leiguarda, R., & Robinson, R.G. (1992). Reliability, validity, and clinical correlates of apathy in Parkinson’s disease. The Journal of Neuropsychiatry and Clinical Neurosciences, 4(2), 134–139. doi: 10.1176/jnp.4.2.134Google ScholarPubMed
Stiasny-Kolster, K., Mayer, G., Schäfer, S., Möller, J.C., Heinzel-Gutenbrunner, M., & Oertel, W.H. (2007). The REM sleep behavior disorder screening questionnaire—A new diagnostic instrument. Movement Disorders, 22(16), 2386–2393. doi: 10.1002/mds.21740CrossRefGoogle ScholarPubMed
Tandberg, E., Larsen, J.P., & Karlsen, K. (1998). A community-based study of sleep disorders in patients with Parkinson’s disease. Movement Disorders, 13(6), 895–899. doi: 10.1002/mds.870130606CrossRefGoogle ScholarPubMed
Tomlinson, C.L., Stowe, R., Patel, S., Rick, C., Gray, R., & Clarke, C.E. (2010). Systematic review of levodopa dose equivalency reporting in Parkinson’s disease. Movement Disorders, 25(15), 2649–2653. doi: 10.1002/mds.23429CrossRefGoogle ScholarPubMed
Van Den Eeden, S.K., Tanner, C.M., Bernstein, A.L., Fross, R.D., Leimpeter, A., Bloch, D.A., & Nelson, L.M. (2003). Incidence of Parkinson’s disease: Variation by age, gender, and race/ethnicity. American Journal of Epidemiology, 157(11), 1015–1022. doi: 10.1093/aje/kwg068CrossRefGoogle Scholar
Vendette, M., Gagnon, J.F., Décary, A., Massicotte-Marquez, J., Postuma, R.B., Doyon, J., … Montplaisir, J. (2007). REM sleep behavior disorder predicts cognitive impairment in Parkinson disease without dementia. Neurology, 69(19), 1843–1849. doi: 10.1212/01.wnl.0000278114.14096.74CrossRefGoogle ScholarPubMed
Walker, M. (2017). Why we sleep: Unlocking the power of sleep and dreams. New York, NY: Scribner.Google Scholar
Wang, Y., Wang, Z.W., Yang, Y.C., Wu, H.J., Zhao, H.Y., & Zhao, Z.X. (2015). Validation of the rapid eye movement sleep behavior disorder screening questionnaire in China. Journal of Clinical Neuroscience, 22(9), 1420–1424. doi: 10.1016/j.jocn.2015.03.008CrossRefGoogle ScholarPubMed
Wechsler, D. (1997). Wechsler Memory Scale–Third Edition, San Antonio, TX: The Psychological Corporation.Google Scholar
Yesavage, J.A., Brink, T.L., Rose, T.L., Lum, O., Huang, V., Adey, M., & Leirer, V.O. (1982). Development and validation of a geriatric depression screening scale: A preliminary report. Journal of Psychiatric Research, 17(1), 37–49. doi: 10.1016/0022-3956(82)90033-4CrossRefGoogle ScholarPubMed
Zhang, J.R., Chen, J., Yang, Z.J., Zhang, H.J., Fu, Y.T., Shen, Y., … Liu, C.F. (2016). Rapid eye movement sleep behavior disorder symptoms correlate with domains of cognitive impairment in Parkinson’s disease. Chinese Medical Journal, 129(4), 379–385. doi: 10.4103/0366-6999.176077CrossRefGoogle ScholarPubMed
Zgaljardic, D.J., Borod, J.C., Foldi, N.S., & Mattis, P. (2003). A review of the cognitive and behavioral sequelae of Parkinson’s disease: Relationship to frontostriatal circuitry. Cognitive and Behavioral Neurology, 16(4). doi: 10.1097/00146965-200312000-00001CrossRefGoogle ScholarPubMed
Zgaljardic, D.J., Borod, J.C., Foldi, N.S., Mattis, P.J., Gordon, M.F., Feigin, A., & Eidelberg, D. (2006). An examination of executive dysfunction associated with frontostriatal circuitry in Parkinson’s disease. Journal of Clinical and Experimental Neuropsychology, 28(7), 1127–1144. doi: 10.1080/13803390500246910CrossRefGoogle ScholarPubMed