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Altered Renal Pathology in an Autoimmune Disease Mouse Model After Induction of Diabetes Mellitus

Published online by Cambridge University Press:  28 May 2021

Shiori Hiramatsu ,
Osamu Ichii Open the ORCID record for Osamu Ichii [Opens in a new window] ,
Takashi Namba ,
Yuki Otani ,
Teppei Nakamura ,
Md. Abdul Masum ,
Yaser Hosny Ali Elewa Open the ORCID record for Yaser Hosny Ali Elewa [Opens in a new window]  and
Yasuhiro Kon
Shiori Hiramatsu
Affiliation:
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Kita 18-Nishi 9, Kita-ku, Sapporo060-0818, Japan
Osamu Ichii*
Affiliation:
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Kita 18-Nishi 9, Kita-ku, Sapporo060-0818, Japan Laboratory of Agrobiomedical Science, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
Takashi Namba
Affiliation:
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Kita 18-Nishi 9, Kita-ku, Sapporo060-0818, Japan
Yuki Otani
Affiliation:
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Kita 18-Nishi 9, Kita-ku, Sapporo060-0818, Japan Laboratory of Agrobiomedical Science, Faculty of Agriculture, Hokkaido University, Sapporo, Japan
Teppei Nakamura
Affiliation:
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Kita 18-Nishi 9, Kita-ku, Sapporo060-0818, Japan Department of Biological Safety Research, Chitose Laboratory, Japan Food Research Laboratories, Chitose, Japan
Md. Abdul Masum
Affiliation:
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Kita 18-Nishi 9, Kita-ku, Sapporo060-0818, Japan Department of Anatomy, Histology and Physiology, Faculty of Animal Science and Veterinary Medicine, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh
Yaser Hosny Ali Elewa
Affiliation:
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Kita 18-Nishi 9, Kita-ku, Sapporo060-0818, Japan Department of Histology and Cytology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt
Yasuhiro Kon
Affiliation:
Laboratory of Anatomy, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Kita 18-Nishi 9, Kita-ku, Sapporo060-0818, Japan
*
*Author for correspondence: Osamu Ichii, E-mail: ichi-o@vetmed.hokudai.ac.jp
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Abstract

Diabetes mellitus (DM) is a predisposing factor for renal disorder progression and is referred to as diabetic kidney disease (DKD). However, there are no reports of DKD with an underlying autoimmune disorder. In this study, we compared the pathophysiological changes caused by DM induction after streptozotocin (STZ) injection in comparison with that in a control group receiving citrate buffer (CB) in the autoimmune disease model mice “BXSB/MpJ-Yaa” (Yaa) and the wild-type strain BXSB/MpJ. Both strains showed hyperglycemia after 12 weeks of STZ injection. Interestingly, the Yaa group developed membranous and proliferative glomerulonephritis, which tended to be milder glomerular lesions in the STZ group than in the CB group, as indicated by a decreased mesangial area and ameliorated albuminuria. Statistically, the indices for hyperglycemia and autoimmune abnormalities were negatively and positively correlated with the histopathological parameters for mesangial matrix production and glomerular proliferative lesions, respectively. STZ treatment induced renal tubular anisonucleosis and dilations in both strains, and they were more severe in Yaa. Significantly decreased cellular infiltration was observed in the Yaa group compared to the CB group. Thus, in DKD related to autoimmune nephritis, hyperglycemia modifies its pathology by decreasing the mesangial area and interstitial inflammation and aggravating renal tubular injury.

Keywords

autoimmune diseaseBXSB/MpJ-Yaadiabetes mellitusdiabetic kidney diseasestreptozotocin
Type
Biological Applications
Information
Microscopy and Microanalysis , Volume 27 , Issue 4 , August 2021 , pp. 897 - 909
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Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

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