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Aminoglycoside Damage to Young Rats Equilibrium

Published online by Cambridge University Press:  02 July 2020

Hirotaka Hara ,
Graciela Meza ,
Barbara Bohne ,
Jun Hara  and
César D. Fermin
Hirotaka Hara
Affiliation:
Pathology. Tulane Medical School, New Orleans, La70112USA.
Graciela Meza
Affiliation:
2Neurosciences, UNAM, Mexico DF.
Barbara Bohne
Affiliation:
Otolaryngology, Univ. of Washington, St. Louis, MO63110USA.
Jun Hara
Affiliation:
Pathology. Tulane Medical School, New Orleans, La70112USA.
César D. Fermin
Affiliation:
Pathology. Tulane Medical School, New Orleans, La70112USA.
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Extract

Chronic streptomycin (STP) administration to young rats for 49 consecutive days intramuscularly affected the rats equilibrium, and balance. Behavioral measures indicated motor-related impairment and rats inability to swim correctly or upright themselves when dunk in a water tank. Moreover, the affected rats failed to walk straight on a inclined platform. Upon termination of the STP administration, motor-related functions returned to pre-administration levels in some animals (recovered group), but not in others (un-recovered group) suggesting that organs involved in maintenance of equilibrium and balance of the body were affected, but later recuperated. The inner ear of both groups and sham controls were processed for histology and transmission electron microscopy and examined.

Twenty day old male Long Evans rats were injected daily in alternating hindlimbs with 400mg/Kg body weight STP. Control rats were injected physiological saline, up to 57 days when they began the recovery period of 8-12 weeks without further injections.

Type
Developmental Biology
Information
Microscopy and Microanalysis , Volume 4 , Issue S2: Proceedings: Microscopy & Microanalysis '98, Microscopy Society of America 56th Annual Meeting, Microbeam Analysis Society 32nd Annual Meeting, Atlanta, Georgia July 12-16, 1998 , July 1998 , pp. 1170 - 1171
Copyright
Copyright © Microscopy Society of America

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References

1.Bohne, B.A. and Carr, C.D., J Accoust Soc Am, 1985. 77(1): p. 153–158.CrossRefGoogle Scholar
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4. Acknowledgement, The authors thank the Dept. of Pathology at Tulane, NASA and the NIH for supporting this work.Google Scholar