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Effects of Cisplatin Administration on the Inducible Nitric Oxide Synthase and Somatostatin in the Pancreatic Islets

Published online by Cambridge University Press:  02 July 2020

Ying Wang  and
Surinder K. Aggarwal
Ying Wang
Affiliation:
Department of Zoology, Michigan State University, East Lansing, MI48824
Surinder K. Aggarwal
Affiliation:
Department of Zoology, Michigan State University, East Lansing, MI48824
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Extract

Cisplatin, a potent broad spectrum anti-cancer agent, has been proven effective in the treatments of bladder, lung, ovarian, head and neck, and testicular cancers. Drawbacks of this chemotherapeutic drug are its toxic side-effects, which include severe nausea, vomiting, stomach distention, peptic ulcer and hyperglycemia. Cisplatin treatment induces the hyperglycemia both in clinical situation and the rodents. Because of the role of the inducible nitric oxide synthase (i-NOS) and somatostatin on the dysfunction of the β-cell of the pancreatic islets and the suppression of the insulin secretion, these were studied using immunocytochemical methods before and after cisplatin treatments using rats.

Wistar rats (100-150 g) were divided into two groups of 6 animals each. One group received injections of cisplatin (9 mg/kg) in 0.85% saline in 5 divided dosages over a 5 days period. The other group received the vehicle of injection only. Rats were killed one day after the last injection.

Type
Cytochemistry, Histochemistry, Immunocytochemistry, and in Situ Hybridization
Information
Microscopy and Microanalysis , Volume 3 , Issue S2: Proceedings: Microscopy & Microanalysis '97, Microscopy Society of America 55th Annual Meeting, Microbeam Analysis Society 31st Annual Meeting, Histochemical Society 48th Annual Meeting, Cleveland, Ohio, August 10-14, 1997 , August 1997 , pp. 163 - 164
Copyright
Copyright © Microscopy Society of America 1997

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References

1.RS, Goldstein-, et al., The effects of cisplatin and other divalent platinum compounds on glucose metabolism and pancreatic endocrine function. Toxicol Appl Pharmacol, 1983, 69: 432-41.Google Scholar
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