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Sem And Tem Observations of Rat Trachea and Lung After Inhalation Injury and Cutaneous Burn In a Rat Model

Published online by Cambridge University Press:  02 July 2020

P.C. Langlinais ,
D.W. Mozingo ,
M.A. Dubick ,
S.C. Carden  and
C.W. Goodwin
P.C. Langlinais
Affiliation:
US Army Institute of Surgical Research, Fort Sam Houston, TX78234
D.W. Mozingo
Affiliation:
Department of Surgery, University of Florida, Gainesville, FL32610
M.A. Dubick
Affiliation:
US Army Institute of Surgical Research, Fort Sam Houston, TX78234
S.C. Carden
Affiliation:
US Army Institute of Surgical Research, Fort Sam Houston, TX78234
C.W. Goodwin
Affiliation:
US Army Institute of Surgical Research, Fort Sam Houston, TX78234
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Extract

Inhalation injury is present in 32-38% of patients with severe burns and is associated with an increase of 20-84% above the mortality expected based on age and burn size alone. Most previous studies of smoke inhalation injury have utilized large animals such as the sheep and we have previously reported a TEM and SEM study of lung injury in the sheep. The present observations are part of a study to develop a small animal combined model of smoke inhalation and surface burn.

Adult, male Sprague-Dawley rats were used. Animals were anesthetized and randomly assigned to one of four groups. Groups 1 and 2 received a 20% total body area surface (TBSA) full thickness scald burns while groups 3 and 4 were sham treated. Five hours after burn injury, rats were placed in a nose only exposure device and half of each group was exposured to either room air alone or room temperature tree bark smoke for 16.25 minutes.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1176 - 1177
Copyright
Copyright © Microscopy Society of America

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References

1.Herndon, D.N. et al., Pulmonary injury in burned patients. Crit Care Clin (1985) 79.CrossRefGoogle Scholar
2.Hubbard, G.B. et al., The morphology of smoke inhalation injury in sheep. Trauma, J (1991) 1477.CrossRefGoogle Scholar