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Ultrastructural Characterization of Hearts from Transgenic Mice Expressing the Epstein-Barr Virus Nuclear Antigen-Leader Protein

Published online by Cambridge University Press:  02 July 2020

J.R. Megill ,
T. M. Monticello ,
M.H. French ,
P.L. Smith ,
N.C. Trippodo  and
S.K. Durham
J.R. Megill
Affiliation:
Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, NJ08543
T. M. Monticello
Affiliation:
Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, NJ08543
M.H. French
Affiliation:
Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, NJ08543
P.L. Smith
Affiliation:
Departments of Experimental Pathology and Cardiovascular Drug Discovery
N.C. Trippodo
Affiliation:
Departments of Experimental Pathology and Cardiovascular Drug Discovery
S.K. Durham
Affiliation:
Pharmaceutical Research Institute, Bristol-Myers Squibb, Princeton, NJ08543
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Extract

Mice expressing the Epstein-Barr virus nuclear antigen-leader protein (EBNA-LP) develop congestive heart failure and atrial thrombosis as early as four months of age. Epstein-Barr virus (EBV) is a common human herpes virus with a complex life cycle involving chronic replication in epithelial tissues. The EBNA-LP, one of six EBV nuclear antigens, has an unknown biochemical function but is associated with EBV-induced growth transformation. This transgenic line was originally produced to investigate oncogenic consequences, but unexpectedly resulted in mice with progressive heart failure. Since the progression and development of the heart failure is highly predictable, this transgenic line may serve as a valuable model for studying the pathophysiologic changes associated with human dilated cardiomyopathy. We describe here the ultrastructural characteristics of the myocardium from EBNA-LP transgenic mice in order to better delineate the pathogenesis of the associated heart disease.

Type
Pathology
Information
Microscopy and Microanalysis , Volume 5 , Issue S2: Proceedings: Microscopy & Microanalysis '99, Microscopy Society of America 57th Annual Meeting, Microbeam Analysis Society 33rd Annual Meeting, Portland, Oregon August 1-5, 1999 , August 1999 , pp. 1172 - 1173
Copyright
Copyright © Microscopy Society of America

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References

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