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Cell stiffness and ROS level alterations in living neurons mediated by β-amyloid oligomers measured by scanning ion-conductance microscopy.

Published online by Cambridge University Press:  30 July 2021

Oleg Suchalko
Affiliation:
National University of Science and Technology “MISiS”, Moscow, Russia, Moskva, Russia
Roman Timoshenko
Affiliation:
National University of Science and Technology "MISIS", Moscow, Moskva, Russia
Alexander Vaneev
Affiliation:
National University of Science and Technology “MISiS”, Russia
Vasilii Kolmogorov
Affiliation:
National University of Science and Technology “MISiS”, Moscow, Russia, Moskva, Russia
Nikita Savin
Affiliation:
National University of Science and Technology "MISIS", Moscow, Russia
Natalia Klyachko
Affiliation:
Lomonosov Moscow State University, Moscow, Russia, Russia
Evgeny Barykin
Affiliation:
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia, United States
Lyubov Gorbacheva
Affiliation:
Russian National Research Medical University, Department of Fundamental and Applied Physiology, Moscow, Russia, United States
Georgy Maksimov
Affiliation:
Lomonosov Moscow State University, Moscow, Russia, United States
Sergei Kozin
Affiliation:
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia, United States
Alexander Erofeev
Affiliation:
National University of Science and Technology “MISiS”, Moscow, Russia, Russia
Yuri Korchev
Affiliation:
National University of Science and Technology "MISIS", Moscow, Russia
Pavel Novak
Affiliation:
National University of Science and Technology “MISiS”, Moscow, Russia, United States
Christopher Edwards
Affiliation:
Imperial College London, London, United Kingdom, United Kingdom
Alexander Majouga
Affiliation:
D. Mendeleev University of Chemical Technology, Russia
Alexander Makarov
Affiliation:
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia, United States
Peter Gorelkin
Affiliation:
National University of Science and Technology “MISiS”, Moscow, Russia, Russia

Abstract

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Type
3D Structures: From Macromolecular Assemblies to Whole Cells (3DEM FIG)
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of the Microscopy Society of America

References

Arbor, S.C., LaFontaine, M., Cumbay, M. (2016). Amyloid-beta Alzheimer targets-protein processing, lipid rafts, and amyloid-beta pores. Yale J Biol Med 89, 5-21.Google ScholarPubMed
Bishop, A. L. and Hall, A. (2000). Rho GTPases and their effector proteins. Biochem. J 348, 241-255.CrossRefGoogle ScholarPubMed
Calamai, M., Evangelisti, E., Cascella, R., Parenti, N., Cecchi, C., Stefani, M., Pavone, F., (2016). Single molecule experiments emphasize GM1 as a key player of the different cytotoxicity of structurally distinct Ab1–42 oligomers. Biochim Biophys Acta 1858 (2), 386392.CrossRefGoogle Scholar
Holmes, C., Boche, D., Wilkinson, D., Yadegarfar, G., Hopkins, V., Bayer, A., Jones, R.W., Bullock, R., Love, S., Neal, J.W. (2008). Long-term effects of Abeta42 immunisation in Alzheimer's disease: Follow-up of arandomised, placebo-controlled phase I trial. Lancet 372, 216-223.Google ScholarPubMed
Korchev, Y. E., Bashford, C. L., Milovanovic, M., Vodyanoy, I., Lab, M. J. (1997). Scanning ion conductance microscopy of living cells. Biophys. J. 73, 653658CrossRefGoogle ScholarPubMed
Mokhtar, S.H., Bakhuraysah, M.M., Cram, D.S., Petratos, S. (2013). The beta-amyloid protein of Alzheimer's disease: communication breakdown by modifying the neuronal cytoskeleton. Int. J. Alzheimer's Dis.Google ScholarPubMed
Verdier, Y., Zarándi, M., Penke, B. (2004). Amyloid b-peptide interactions with neuronal and glial cell plasma membrane: Binding sites and implications for Alzheimer's disease. J. Pept. Sci. 10 (5), 229248.CrossRefGoogle Scholar
Ungureanu, A., Benilova, I., Krylychkina, O., Braeken, D. (2016). Amyloid beta oligomers induce neuronal elasticity changes in age-dependent manner: a force spectroscopy study on living hippocampal neurons. Sci. Rep. 6, 113.CrossRefGoogle Scholar
Mendoza-Naranjo, A., Gonzalez-Billault, C., Maccioni, R.B. (2006). Aβ1-42 stimulates actin polymerization in hippocampal neurons through Rac1 and Cdc42 Rho GTPases. Journal of Cell Science 120, 279-288.CrossRefGoogle Scholar