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Chronic Ingestion of High-Fat Diet and Energy Restriction Modulates Expression of VEGF and VEGFR2 in Aged Rat Myocardium

Published online by Cambridge University Press:  28 September 2012

D. Fernandes ,
I. Tomada ,
H. Almeida  and
D. Neves
D. Fernandes
Affiliation:
Department of Experimental Biology, Faculty of Medicine and IBMC of Universidade do Porto, 4200-319 Porto, Portugal
I. Tomada
Affiliation:
Department of Experimental Biology, Faculty of Medicine and IBMC of Universidade do Porto, 4200-319 Porto, Portugal
H. Almeida
Affiliation:
Department of Experimental Biology, Faculty of Medicine and IBMC of Universidade do Porto, 4200-319 Porto, Portugal
D. Neves
Affiliation:
Department of Experimental Biology, Faculty of Medicine and IBMC of Universidade do Porto, 4200-319 Porto, Portugal

Abstract

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Cardiovascular diseases (CVD) constitute a leading cause of death in the aged population. Regular intake of hyperlipidic diet and obesity can induce endothelial dysfunction that precedes the onset of atherosclerosis and CVD. High-fat diet regular consumption leads to structural modifications in heart tissue, and changes in the expression of angiogenic factors and their specific receptors. Hence, we aimed to characterize the expression pattern of vascular endothelial growth factor (VEGF) and its membrane receptor VEGFR 2 in young and aged rat hearts under high-fat diet and energy restriction.

Type
Life Sciences
Information
Microscopy and Microanalysis , Volume 18 , Supplement S5: Portuguese Supplement , August 2012 , pp. 7 - 8
Copyright
Copyright © Microscopy Society of America 2012