Hostname: page-component-5c6d5d7d68-pkt8n Total loading time: 0 Render date: 2024-09-01T16:23:08.356Z Has data issue: false hasContentIssue false
  • English
  • Français

Improving Protein-ligand Modeling into Cryo-EM Data and the Use of Those Models in Drug Discovery Efforts

Published online by Cambridge University Press:  30 July 2020

Kenneth Borrelli
Kenneth Borrelli*
Affiliation:
Schrodinger, Inc, New York, New York, United States

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Image Processing Developments in Cryo-EM
Information
Microscopy and Microanalysis , Volume 26 , Supplement S2 , August 2020 , pp. 2298 - 2299
Check for updates
Copyright
Copyright © Microscopy Society of America 2020

References

GemSpot: A Pipeline for Robust Modeling of Ligands into CryoEM MapsGoogle Scholar
Robertson, Michael J., van Zundert, Gydo C. P., Borrelli, Kenneth, Skiniotis, Georgios bioRxiv 750778; doi: https://doi.org/10.1101/750778CrossRefGoogle Scholar
Li, Qi; Pellegrino, Jenna; Lee, D. John; Tran, Arthur; Wang, Ruoxi; Park, Jesslyn;, et al. (2019): Synthesis and Mechanism of Action of Group a Streptogramin Antibiotics That Overcome Resistance. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.8346107.v2CrossRefGoogle Scholar
Wei, J, Leit, S, Kuai, J, Therrien, E, Rafi, S, Harwood, HJ Jr, DeLaBarre, B, Tong, L. An allosteric mechanism for potent inhibition of human ATP-citrate lyase. Nature. 2019 Apr;568(7753):566-570.10.1038/s41586-019-1094-6CrossRefGoogle Scholar