Gluteraldehyde (GA) has proven to be an extraordinarily versatile product. Its many uses range from softening leather and paper to disinfecting and sterilizing hospital instruments. It is used, of course, as a fixative in preparing biological samples for microscopic investigations that most readers of this publication will be familiar with. Even though quality questions relating to GA have been well researched and documented, there is still enough disagreement between industry experts to stimulate an enthusiastic discussion on microscopic list servers.