Fluorescence microscopy has revolutionized cell biology. Not only has it increased the spatial resolution with which certain processes are visualized, but it has allowed microscopists to monitor more than one event at a time. One of the remaining challenges is to see how proteins fold and assume their native conformations within living cells. Recently, Nathan Luedtke, Rachel Dexter, Daniel Fried, and Alanna Schepartz have demonstrated a technique to demonstrate these events in situ.