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Application of AFM to the Nanomechanics of Cancer

Published online by Cambridge University Press:  11 April 2016

Shivani Sharma  and
James K Gimzewski
Shivani Sharma
Affiliation:
California NanoSystems Institute, Los Angeles, California, USA
James K Gimzewski*
Affiliation:
California NanoSystems Institute, Los Angeles, California, USA Department of Chemistry and Biochemistry, University of California, Los Angeles, California, USA International Center for Materials Nanoarchitectonics Satellite (MANA), National Institute for Materials Science (NIMS), Tsukuba, Japan
*
*(Email: gimzewski@cnsi.ucla.edu)
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Abstract

Cancer cell metastasis is a leading cause of mortality whereby cancer cells migrate from a tumor and spread to distant sites in the body. Understanding metastasis requires a deeper understanding of biomechanics and mechanobiology at the cellular level. We have established the use of Atomic Force Microscopy to infer the mechanical properties of single cells in cultures by measurement of their Young’s modulus. Here we discuss the main advantages, challenges, technological limitations and applicability of AFM based cell mechanics studies along with other emerging high throughput techniques for the development of single cell mechanical based clinical assays for cancer detection and management.

Keywords

nano-indentationbiomaterialbiomedical
Type
Articles
Information
MRS Advances , Volume 1 , Issue 25: Theory, Characterization, and Modeling , 2016 , pp. 1817 - 1827
Copyright
Copyright © Materials Research Society 2016 

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References

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