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Application of Gold and Platinum Bimetallic Nanoparticle to enhance Surface Plasmon Resonance Signal

Published online by Cambridge University Press:  23 June 2020

Lucca Silva Nascimento Open the ORCID record for Lucca Silva Nascimento [Opens in a new window] ,
Erenildo Ferreira Macedo ,
Jéssica Aparecida Magalhães ,
Luísa Rodrigues Molina Dona'  and
Dayane Batista Tada
Lucca Silva Nascimento
Affiliation:
Laboratory of Nanomaterials and Nanotechnology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Rua Talim 330, Vila Nair, São José dos Campos12231-280, SP, Brazil; lucca.silva@unifesp.br (L.S.d.N.); e.macedo@unifesp.br (E.F.d.M.); Jmagalhaaes@gmail.com (J.A. d.M.); luisa.r.m.dona@gmail.com (L.R.M. d D.).
Erenildo Ferreira Macedo
Affiliation:
Laboratory of Nanomaterials and Nanotechnology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Rua Talim 330, Vila Nair, São José dos Campos12231-280, SP, Brazil; lucca.silva@unifesp.br (L.S.d.N.); e.macedo@unifesp.br (E.F.d.M.); Jmagalhaaes@gmail.com (J.A. d.M.); luisa.r.m.dona@gmail.com (L.R.M. d D.).
Jéssica Aparecida Magalhães
Affiliation:
Laboratory of Nanomaterials and Nanotechnology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Rua Talim 330, Vila Nair, São José dos Campos12231-280, SP, Brazil; lucca.silva@unifesp.br (L.S.d.N.); e.macedo@unifesp.br (E.F.d.M.); Jmagalhaaes@gmail.com (J.A. d.M.); luisa.r.m.dona@gmail.com (L.R.M. d D.).
Luísa Rodrigues Molina Dona'
Affiliation:
Laboratory of Nanomaterials and Nanotechnology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Rua Talim 330, Vila Nair, São José dos Campos12231-280, SP, Brazil; lucca.silva@unifesp.br (L.S.d.N.); e.macedo@unifesp.br (E.F.d.M.); Jmagalhaaes@gmail.com (J.A. d.M.); luisa.r.m.dona@gmail.com (L.R.M. d D.).
Dayane Batista Tada*
Affiliation:
Laboratory of Nanomaterials and Nanotechnology, Instituto de Ciência e Tecnologia, Universidade Federal de São Paulo, Rua Talim 330, Vila Nair, São José dos Campos12231-280, SP, Brazil; lucca.silva@unifesp.br (L.S.d.N.); e.macedo@unifesp.br (E.F.d.M.); Jmagalhaaes@gmail.com (J.A. d.M.); luisa.r.m.dona@gmail.com (L.R.M. d D.).
*
*To whom correspondence should be addressed: Dr. Dayane Batista Tada, email: d.tada@unifesp.br
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Abstract

Sensors based on the surface plasmon resonance (SPR) technique are useful devices to detect and monitor interactions between biomolecules in real-time. SPR is a label-free method that monitors the variation of reflectivity of a biochip composed of a metal-coated glass prism and can be applied in several areas, such as biotechnology, food safety and clinical diagnosis. In the last years, several researchers have proven the efficiency of metallic nanoparticles (NPs) in the enhancement of SPR signal. This feature allowed the detection of biomolecules at very low concentration. Aiming to further enhance SPR signal towards the detection of proteins at low concentration and by a simple procedure, the present work compared the performance of gold and platinum bimetallic NPs (AuPtNPs) with that of monometallic gold NPs (AuNPs) in the enhancement of SPR signal. In order to evaluate the NPs, protein peanut agglutin (PNA) was used as target analyte and anti-PNA antibody was used as sensing molecule. Firstly NPs were functionalized with anti-PNA antibody and incubated with a solution containing PNA. Then, the NPs bound to PNA were injected into the SPR equipment containing a biochip previously modified with anti-PNA antibody. The results demonstrated that the AuPtNPs provided a 91-fold increase compared to the direct detection of free PNA in solution. In comparison with AuNPs, the signal generated by AuPtNPs was about 4 times higher. This encouraging result indicated that the application of bimetallic NPs may be a better strategy to further enhance sensitivity of SPR biosensors and could drive the development of new strategies that are not only simple, but also able to detect proteins at low concentrations, which is of great importance, especially in clinical diagnostics.

Type
Articles
Information
MRS Advances , Volume 5 , Issue 42: Nanoscale and Quantum Materials , 2020 , pp. 2181 - 2189
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Copyright
Copyright © Materials Research Society 2020

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