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Cartilage: Multiscale Structure and Biomechanical Properties

Published online by Cambridge University Press:  10 March 2016

Ferenc Horkay ,
Peter J. Basser ,
Anne-Marie Hecht  and
Erik Geissler
Ferenc Horkay*
Affiliation:
Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA
Peter J. Basser
Affiliation:
Section on Quantitative Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, 20892, USA
Anne-Marie Hecht
Affiliation:
Université Grenoble Alpes, Laboratoire Interdisciplinaire de Physique, and CNRS, LIPhy, F-38000 Grenoble, France.
Erik Geissler
Affiliation:
Université Grenoble Alpes, Laboratoire Interdisciplinaire de Physique, and CNRS, LIPhy, F-38000 Grenoble, France.
*
*(Email: horkayf@helix.nih.gov)
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Abstract

Cartilage is a load bearing tissue that has multiple biological functions. The major proteoglycan in cartilage is the bottlebrush shaped aggrecan whose complexes with hyaluronic acid provide the compressive resistance of cartilage. The negatively charged aggrecan-hyaluronic acid complexes generate an osmotic swelling pressure within the tissue, which is balanced by the collagen network. To better understand the function of cartilage at the tissue level, we study aggrecan assemblies using an array of microscopic and macroscopic techniques. The organization of aggrecan assemblies at the supramolecular level is probed by light scattering, small-angle neutron scattering and small-angle X-ray scattering. Osmotic and rheological measurements are used to investigate the macroscopic physical properties.

Keywords

neutron scatteringosmosispolymer
Type
Articles
Information
MRS Advances , Volume 1 , Issue 8: Biomaterials and Soft Materials , 2016 , pp. 509 - 519
Copyright
Copyright © Materials Research Society 2016 

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References

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