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The contribution of cell-cell signaling and motility to bacterial biofilm formation

Published online by Cambridge University Press:  18 May 2011

Joshua D. Shrout ,
Tim Tolker-Nielsen ,
Michael Givskov  and
Matthew R. Parsek
Joshua D. Shrout
Affiliation:
University of Notre Dame, IN 46556, USA; joshua.shrout@nd.edu
Tim Tolker-Nielsen
Affiliation:
University of Copenhagen, Denmark; ttn@sund.ku.dk
Michael Givskov
Affiliation:
University of Copenhagen, Denmark; mgivskov@sund.ku.dk
Matthew R. Parsek
Affiliation:
University of Washington, Seattle 98195, USA; parsem@u.washington.edu
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Abstract

Many bacteria grow attached to a surface as biofilms. Several factors dictate biofilm formation, including responses by the colonizing bacteria to their environment. Here we review how bacteria use cell-cell signaling (also called quorum sensing) and motility during biofilm formation. Specifically, we describe quorum sensing and surface motility exhibited by the bacterium Pseudomonas aeruginosa, a ubiquitous environmental organism that acts as an opportunistic human pathogen in immunocompromised individuals. P. aeruginosa uses acyl-homoserine lactone signals during quorum sensing to synchronize gene expression important to the production of polysaccharides, rhamnolipid, and other virulence factors. Surface motility affects the assembly and architecture of biofilms, and some aspects of motility are also influenced by quorum sensing. While some genes and their function are specific to P. aeruginosa, many aspects of biofilm development can be used as a model system to understand how bacteria differentially colonize surfaces.

Type
Research Article
Information
MRS Bulletin , Volume 36 , Issue 5: All together now: Integrating biofilm research across disciplines , May 2011 , pp. 367 - 373
Copyright
Copyright © Materials Research Society 2011

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