Hostname: page-component-7479d7b7d-pfhbr Total loading time: 0 Render date: 2024-07-13T18:43:16.024Z Has data issue: false hasContentIssue false
  • English
  • Français

The Intersection of Biology and Materials Science

Published online by Cambridge University Press:  31 January 2011

George M. Whitesides  and
Amy P. Wong
Get access

Abstract

This article is based on the plenary address given by George M. Whitesides of Harvard University on March 30, 2005, at the Materials Research Society Spring Meeting in San Francisco. Materials science and biomedicine are arguably two of the most exciting fields in science today. Research at the border between them will inevitably be a major focus, and the applications of materials science to problems in biomedicine—that is, biomaterials science—will bud into an important new branch of materials science. Accelerating the growth of this area requires an understanding of two very different fields, and being both thoughtful and entrepreneurial in considering “Why?” “How?” and “Where?” to put them together. In this fusion, biomedicine will, we believe, set the agenda; materials science will follow, and materials scientists must learn biology to be effective.

Keywords

biologicalbiomedicalnanoscale.
Type
Research Article
Information
MRS Bulletin , Volume 31 , Issue 1 , January 2006 , pp. 19 - 27
Copyright
Copyright © Materials Research Society 2006

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1Hummel, R.Understanding Materials Science: History, Properties, Applications, 2nd ed. (Springer, Berling, 2004).CrossRefGoogle Scholar
2Suuronen, E.J.Sheardown, H.Newman, K.D.McLaughlin, C.R. and Griffith, M. in International Review of Cytology—a Survey of Cell Biology 244 (2005) p. 137.Google Scholar
3Chen, G.Q. and Wu, Q.Biomaterials 26 (2005) p. 6565.CrossRefGoogle Scholar
4Davis, M.E.Hsieh, P.C.H.Grodzinsky, A.J. and Lee, R.T.Circ. Res. 97 (2005) p. 8.CrossRefGoogle Scholar
5Kriplani, U. and Kay, B.K.Curr. Opin. Biotechnol. 16 (2005) p. 470.CrossRefGoogle Scholar
6Morra, M.Biomacromolecules 6 (2005) p. 1205.CrossRefGoogle Scholar
7Rosso, F.Marino, G.Giordano, A.Barbarisi, M.Parmeggiani, D. and Barbarisi, A.J. Cell. Physiol. 203 (2005) p. 465.CrossRefGoogle Scholar
8Sanford, K. and Kumar, M.Curr. Opin. Biotechnol. 16 (2005) p. 416.CrossRefGoogle Scholar
9Santerre, J.P.Woodhouse, K.Laroche, G. and Labow, R.S.Biomaterials 26 (2005) p. 7457.CrossRefGoogle Scholar
10Ratner, B.Hoffman, A.S.Schoen, F.J. and Lemons, J.E.Biomaterials Science: An Introduction to Materials in Medicine (Academic Press, New York, 1997).Google Scholar
11Standal, T.Borset, M. and Sundan, A.Exp. Oncol. 26 (2004) p. 179.Google Scholar
12Hruska, K.A.Mathew, S. and Saab, G.Circ. Res. 97 (2005) p. 105.CrossRefGoogle Scholar
13Takeda, S.Biochem. Biophys. Res. Commun. 328 (2005) p. 697.CrossRefGoogle Scholar
14Stains, J.P. and Civitelli, R.Biochem. Biophys. Res. Commun. 328 (2005) p. 721.CrossRefGoogle Scholar
15Brunetti, P.Federici, M.O. and Benedetti, M.M.Artif. Cells Blood Substit. Immobil. Biotechnol. 31 (2003) p. 127.CrossRefGoogle Scholar
16Jiang, X.Y.Bruzewicz, D.A.Wong, A.P.Piel, M. and Whitesides, G.M.Proc. Natl. Acad. Sci. U.S.A. 102 (2005) p. 975.CrossRefGoogle Scholar
17Mrksich, M.Chen, C.S.Xia, Y.N.Dike, L.E.Ingber, D.E. and Whitesides, G.M.Proc. Natl. Acad. Sci. U.S.A. 93 (1996) p. 10775.CrossRefGoogle Scholar
18Mrksich, M. and Whitesides, G.M.Annu. Rev. Biophys. Biomolec. Struct. 25 (1996) p. 55.CrossRefGoogle Scholar
19Ostuni, E.Yan, L. and Whitesides, G. M.Colloids Surf. B Biointerfaces 15 (1999) p. 3.CrossRefGoogle Scholar
20Chen, D.L.Gerdts, C.J. and Ismagilov, R.F.J. Am. Chem. Soc. 127 (2005) p. 9672.CrossRefGoogle Scholar
21Woerd, M. van der, Ferree, D. and Pusey, M.J. Struct. Biol. 142 (2003) p. 180.CrossRefGoogle Scholar
22Hansen, C. and Quake, S.R.Curr. Opin. Struct. Biol. 13 (2003) p. 538.CrossRefGoogle Scholar
23Wilt, F.H.Develop. Biol. 280 (2005) p. 15.CrossRefGoogle Scholar
24Wu, L.Q. and Payne, G.F.Trends Biotechnol. 22 (2004) p. 593.CrossRefGoogle Scholar
25Ben-Nissan, B., Curr. Opin. Solid State Mater. Sci. 7 (2003) p. 283.CrossRefGoogle Scholar
26Barakat, I.Dubois, P.Grandfils, C.Jerome, R.J. Polym. Sci. Part A: Polym. Chem. 37 (1999) p. 2401.3.0.CO;2-9>CrossRefGoogle Scholar
27Ramachandran, S.Tseng, Y. and Yu, Y.B.Biomacromolecules 6 (2005) p. 1316.CrossRefGoogle Scholar
28Schneider, J.P.Pochan, D.J.Ozbas, B.Rajagopal, K.Pakstis, L. and Kretsinger, J.J. Am. Chem. Soc. 124 (2002) p. 15030.CrossRefGoogle Scholar
29Caplan, M.R.Schwartzfarb, E.M.Zhang, S.G.Kamm, R.D. and Lauffenburger, D.A.J. Biomater. Sci. Polym. Ed. 13 (2002) p. 225.CrossRefGoogle Scholar
30Caplan, M.R.Schwartzfarb, E.M.Zhang, S.G.Kamm, R.D. and Lauffenburger, D.A.Biomaterials 23 (2002) p. 219.CrossRefGoogle Scholar
31Langer, R. and Tirrell, D.A.Nature 428 (2004) p. 487.CrossRefGoogle Scholar
32Ruszczak, Z.Adv. Drug Deliv. Rev. 55 (2003) p. 1595.CrossRefGoogle Scholar
33Martin, D.P. and Williams, S.F.Biochem. Eng. J. 16 (2003) p. 97.CrossRefGoogle Scholar
34Lutolf, M.P. and Hubbell, J.A.Nat. Biotechnol. 23 (2005) p. 47.CrossRefGoogle Scholar
35Roy, I. and Gupta, M.N.Chem. Biol. 10 (2003) p. 1161.CrossRefGoogle Scholar
36Cui, D.X. and Gao, H.J.Biotechnol. Progr. 19 (2003) p. 683.CrossRefGoogle Scholar
37Barron, A.E. and Zuckermann, R.N.Curr. Opin. Chem. Biol. 3 (1999) p. 681.CrossRefGoogle Scholar
38Pannier, A.K. and Shea, L.D.Mol. Ther. 10 (2004) p. 19.CrossRefGoogle Scholar
39Kashyap, N.Kumar, N. and Kumar, M.Crit. Rev. Ther. Drug Carrier Syst. 22 (2005) p. 107.CrossRefGoogle Scholar
40Tamber, H.Johansen, P.Merkle, H.P. and Gander, B.Adv. Drug Delivery Rev. 57 (2005) p. 357.CrossRefGoogle Scholar
41Jiang, W.L.Gupta, R.K.Deshpande, M.C. and Schwendeman, S.P.Adv. Drug Delivery Rev. 57 (2005) p. 391.CrossRefGoogle Scholar
42Whittlesey, K.J. and Shea, L.D.Exp. Neurol. 190 (2004) p. 1.CrossRefGoogle Scholar
43Lu, Y. and Chen, S.C.Adv. Drug Delivery Rev. 56 (2004) p. 1621.CrossRefGoogle Scholar
44Desgrandchamps, F. and Griffith, D.P.Eur. Urol. 35 (1999) p. 257.Google Scholar
45Grigioni, M.Caprari, P.Tarzia, A. and D'Avenio, G., J. Biomechan. 38 (2005) p. 1557.CrossRefGoogle Scholar
46Malchesky, P.S.Artif. Organs 28 (2004) p. 410.CrossRefGoogle Scholar
47Chang, T.M.S.Artif. Cells Blood Substit. Immobil. Biotechnol. 31 (2003) p. 151.CrossRefGoogle Scholar
48Famulari, A.Simone, P. De, Verzaro, R.Iaria, G.Polisetti, F.Rascente, M. and Aureli, A.Artif. Cells Blood Substit. Immobil. Biotechnol. 31 (2003) p. 163.CrossRefGoogle Scholar
49Greenhalgh, D.G.J. Burn Care Rehabil. 26 (2005) p. 293.CrossRefGoogle Scholar
50Hildebrand, K.A.Gallant-Behm, C.L., Kydd, A.S. and Hart, D.A.Sports Med. Arthroscopy Rev. 13 (2005) p. 136.CrossRefGoogle Scholar
51Yamada, T. and Kawasaki, T.J. Biosci. Bioeng. 99 (2005) p. 521.CrossRefGoogle Scholar
52Zelenka, P.S. and Smith, J.Expert Opin. Ther. Patents 15 (2005) p. 875.CrossRefGoogle Scholar
53Weisel, J.W. in Fibrous Proteins: Coiled-Coils, Collagen and Elastomers 70 (2005) p 247.Google Scholar
54Peppas, N.A.Huang, Y.Torres-Lugo, M., Ward, J.H. and Zhang, J. Annu. Rev. Biomed. Eng. 2 (2000) p. 9.CrossRefGoogle Scholar
55Fuente, J.M. de la, Fandel, M.Berry, C.C.Riehle, M.Cronin, L.Aitchison, G. and Curtis, A.S.G.Chembiochem 6 (2005) p. 989.CrossRefGoogle Scholar
56Medintz, I.L.Uyeda, H.T.Goldman, E.R. and Mattoussi, H.Nat. Mater. 4 (2005) p. 435.CrossRefGoogle Scholar
57Tan, Y.Ding, S.H.Wang, Y. and Qian, W.P.Acta Chim. Sinica 63 (2005) p. 929.Google Scholar
58Pellegrino, T.Kudera, S.Liedl, T.Javier, A.M.Manna, L. and Parak, W.J.Small 1 (2005) p. 48.CrossRefGoogle Scholar
59Smith, D.K.Hirst, A.R.Love, C.S.Hardy, J.G.Brignell, S.V. and Huang, B.Q.Progr. Polym. Sci. 30 (2005) p. 220.CrossRefGoogle Scholar
60Moghimi, S.M.Hunter, A.C. and Murray, J.C.FASEB J. 19 (2005) p. 311.CrossRefGoogle Scholar
61Gao, X.H.Yang, L.L.Petros, J.A.Marshal, F.F.Simons, J.W. and Nie, S.M.Curr. Opin. Biotechnol. 16 (2005) p. 63.CrossRefGoogle Scholar
62Oberdorster, G. and Oberdorster, E.J. Environ. Health Perspect. 113 (2005) p. 823.CrossRefGoogle Scholar
63Lovric, J.Bazzi, H.S.Cuie, Y.Fortin, G.R.A.Winnik, F.M. and Maysinger, D.J. Mol. Med.-JMM 3 (2005) p. 377.CrossRefGoogle Scholar
64Lee, B.I.Qi, L. and Copeland, T.J. Ceram. Proc. Res. 6 (2005) p. 31.Google Scholar
65Turner, J.L.Pan, D.P.J.Plummer, R.Chen, Z.Y.Whittaker, A.K. and Wooley, K.L.Adv. Funct. Mater. 15 (2005) p. 1248.CrossRefGoogle Scholar
66Wissing, S.A.Kayser, O. and Muller, R.H.Adv. Drug Delivery Rev. 56 (2004) p. 1257.CrossRefGoogle Scholar
67Li, Z.Zhu, S.G.Gan, K.Zhang, Q.H.Zeng, Z.Y.Zhou, Y.H.Liu, H.Y.Xiong, W.Li, X.L. and Li, G.Y.J. Nanosci. Nanotechnol. 5 (2005) p. 1199.CrossRefGoogle Scholar
68Hu, S.H.Eberhard, L.Chen, J.X.Love, J.C.Butler, J.P.Fredberg, J.J.Whitesides, G.M. and Wang, N.Am. J. Physiol. Cell Physiol. 287 (2004) p. C1184.CrossRefGoogle Scholar
69El-Hakim, I.E., Azim, A.M.A.El-Hassan, M.F.A., and Maree, S.M.Int. J. Oral Maxillofac. Surg. 33 (2004) p. 42.CrossRefGoogle Scholar
70Driban, J.B.Athl. Ther. Today 9 (2004) p. 22.CrossRefGoogle Scholar
71Park, S.H. and Silva, M.J. Orthopaedic Res. 22 (2004) p. 382.CrossRefGoogle Scholar