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Multimaterial, heterogeneous, and multicellular three-dimensional bioprinting

Published online by Cambridge University Press:  10 August 2017

Carmelo De Maria ,
Giovanni Vozzi  and
Lorenzo Moroni
Carmelo De Maria
Affiliation:
Department of Ingegneria dell’Informazione and Research Center E. Piaggio, University of Pisa, Italy; carmelo.demaria@centropiaggio.unipi.it
Giovanni Vozzi
Affiliation:
Department of Ingegneria dell’Informazione and Research Center E. Piaggio, University of Pisa, Italy; g.vozzi@ing.unipi.it
Lorenzo Moroni
Affiliation:
MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, The Netherlands; l.moroni@maastrichtuniversity.nl
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Abstract

Bioprinting promises to create three-dimensional in vitro models to study pathological states and possible new therapies, and in the future, to produce complex tissue and organ replacements. This article will describe the recent advances in bioprinting technologies to engineer artificial tissues and organs by controlling spatial heterogeneity of chemical and physical properties of scaffolds and, at the same time, the cellular composition and spatial arrangement. Despite significant technological improvements in recent years, the positioning at the micrometric level and the switching of different cell types and biomaterials remain a challenge, which limits the development of resilient vascular, neural, and lymphatic networks for metabolites, signaling, and waste transport, and thus limits the development of thick and clinically relevant engineered vascularized tissues.

Keywords

biomimetic (assembly)microstructureextrusionink-jet printing
Type
Research Article
Information
MRS Bulletin , Volume 42 , Issue 8: 3D Bioprinting of Organs , August 2017 , pp. 578 - 584
Copyright
Copyright © Materials Research Society 2017 

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