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PC-12 cells adhesion and differentiation on carbon aerogel scaffolds

Published online by Cambridge University Press:  05 November 2018

Martina Rodriguez Sala ,
Kyle J. Lynch ,
Swetha Chandrasekaran ,
Omar Skalli ,
Marcus Worsley  and
Firouzeh Sabri
Martina Rodriguez Sala
Affiliation:
Department of Physics and Materials Science, University of Memphis, Memphis, TN 38152, USA
Kyle J. Lynch
Affiliation:
Department of Physics and Materials Science, University of Memphis, Memphis, TN 38152, USA
Swetha Chandrasekaran
Affiliation:
Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
Omar Skalli
Affiliation:
Department of Biological Sciences, University of Memphis, Memphis, TN 38152, USA
Marcus Worsley
Affiliation:
Lawrence Livermore National Laboratory, Livermore, CA 94550, USA
Firouzeh Sabri*
Affiliation:
Department of Physics and Materials Science, University of Memphis, Memphis, TN 38152, USA
*
Address all correspondence to Firouzeh Sabri at fsabri@memphis.edu
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Abstract

Electrically conducting substrates have shown much promise as neuronal scaffolds and in other biologic and biomedical applications where a smart and electrically interactive material is needed. Most materials that are inherently conducting are not suitable for biomedical applications and lack biocompatibility or biostability. On the other hand, biologically stable and compatible materials must first be manipulated, modified, and treated in order to impart the necessary electrical conductivity to the material. Here, the authors have investigated the response of PC-12 cells to two types of conducting carbon-based aerogels with different surface roughness. Results show that carbon-based aerogels support cell adhesion, proliferation, and neurite extension. The effects of surface roughness have also been investigated.

Type
Research Letters
Information
MRS Communications , Volume 8 , Issue 4 , December 2018 , pp. 1426 - 1432
Copyright
Copyright © Materials Research Society 2018 

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