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Prevention of Candida biofilm formation over polystyrene by plasma polymerization technique

Published online by Cambridge University Press:  15 October 2020

Gizem Kaleli-Can ,
Elvan Hortaç-İştar ,
Hatice Ferda Özgüzar ,
Mehmet Mutlu ,
Hasan Cenk Mirza ,
Ahmet Başustaoğlu  and
Julide Sedef Göçmen
Gizem Kaleli-Can
Affiliation:
Department of Biomedical Engineering, İzmir Democracy University, İzmir35140, Turkey
Elvan Hortaç-İştar
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara06790, Turkey
Hatice Ferda Özgüzar
Affiliation:
Biomedical Engineering Division, Graduate School of Science and Technology, TOBB University of Economics and Technology, Ankara06560, Turkey
Mehmet Mutlu
Affiliation:
Department of Mechanical Engineering, Ostim Technical University, Ankara06374, Turkey
Hasan Cenk Mirza
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara06790, Turkey
Ahmet Başustaoğlu
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, Başkent University, Ankara06790, Turkey
Julide Sedef Göçmen*
Affiliation:
Department of Medical Microbiology, Faculty of Medicine, TOBB University of Economics and Technology, Ankara06560, Turkey
*
Address all correspondence to Julide Sedef Göçmen at jgocmen@etu.edu.tr
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Abstract

This work investigates the antifungal effect of plasma polymer films produced by low-pressure RF-generated plasma system using acrylic acid, 2–hydroxyethyl methacrylate, and diethyl phosphite (DEP). Unmodified and plasma-modified polystyrene (PS) microplate wells were tested by 30 biofilm-positive Candida spp. isolated from blood samples and two control strains using a quantitative plaque assay method. Regardless of the precursors and plasma parameters, biofilm formation was inhibited for all plasma-modified microplate wells. The most significant anti-biofilm effect was observed on PS modified by DEP at 90 W plasma power with the inhibition of all Candida species’ biofilm formation.

Type
Research Letters
Information
MRS Communications , Volume 10 , Issue 4 , December 2020 , pp. 667 - 673
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Copyright
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

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