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ABA triblock copolymer based hydrogels with thermo-sensitivity for biomedical applications

Published online by Cambridge University Press:  28 June 2013

Lucile Tartivel ,
Marc Behl ,
Michael Schroeter  and
Andreas Lendlein
Lucile Tartivel
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany. Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany.
Marc Behl
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany.
Michael Schroeter
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany.
Andreas Lendlein
Affiliation:
Institute of Biomaterial Science and Berlin-Brandenburg Center for Regenerative Therapies (BCRT), Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany. Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany.
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Abstract

Oligo(ethylene glycol)-oligo(propylene glycol)-oligo(ethylene glycol) (OEG-OPG-OEG) triblock copolymers are hydrogel forming and extensively investigated in the field of drug release due to their biocompatibility and thermo-sensitivity. Here the synthesis and characterization of OEG-OPG-OEG based polymer networks from methacrylated oligomers by photo-irradiation are reported. Two precursors were selected to have comparable hydrophilicity (80 wt% OEG content) but different molecular weights of Mn = 8400 g·mol-1 and 14600 g·mol-1. The precursor solutions were prepared in concentration 10 to 30 wt%. The resulting polymer networks prepared from high Mn precursors exhibited higher swellability at equilibrium (up to 3400%) and mechanical properties in the range of G’ ∼ 0.1 to 1 kPa at 5 °C compared to networks based on low Mn precursors. A more significant thermo-sensitive behavior in terms of swellability, volumetric contraction and mechanical transition, starting at 30 °C could also be observed for the networks based on high Mn precursors, thus promoting future application in the field of drug release.

Keywords

polymerbiomaterialchemical reaction
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1569: Symposium NN – Advanced Materials for Biological and Biomedical Applications , 2013 , pp. 135 - 140
Copyright
Copyright © Materials Research Society 2013 

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References

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