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Alginate Based Microparticle Drug Delivery Systems for the Treatment of Eye Cancer

Published online by Cambridge University Press:  31 January 2011

Yerkesh O Batyrbekov ,
Dinara Rakhimbaeva ,
Kuanyshbek Musabekov  and
Bulat Zhubanov
Yerkesh O Batyrbekov
Affiliation:
erkeshbatyrbekov@mail.ru, Institute of Chemical Sciences, 106 Valikhanov Street, Almaty, 050010, Kazakhstan
Dinara Rakhimbaeva
Affiliation:
dinararakhim@mail.ru, Kazakh State University, Almaty, Kazakhstan
Kuanyshbek Musabekov
Affiliation:
kuan@nursat.kz, Kazakh State University, Almaty, Kazakhstan
Bulat Zhubanov
Affiliation:
bulatzhubanov@mail.ru, Institute of Chemical Sciences, Almaty, Kazakhstan
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Abstract

Alginate based microparticle drug delivery systems were prepared for the sustained release of antitumor drugs. Two drugs, cyclophosphane and 5-fluorouracil, were encapsulated into the microparticles. The drug loaded microparticles were fabricated using a very convenient method under very mild conditions by the gelation of alginate with calcium cation. Modified microparticles were obtained by syringed dropwise a solution of drugs in sodium alginate into chitosan solution in calcium chloride. The effect of polymers concentration and the drug loading (1.0, 5.0 and 10%) on the release profile of drugs were investigated. The amount of drug release was much higher initially (approximately 25%), followed by a constant slow release profile. All the release data show the typical pattern for a matrix controlled mechanism. The cumulative amount of drug released from alginate gels was linearly related to the square root of the time and the release rate decreased this time. The process is controlled by the diffusion of antitumor drugs through the chitosan coating. Scanning electron microscopy (SEM) and particle size analysis revealed differences between the formulations as to their appearance and size distribution. The experiments for anticancer action of alginate microparticles were determined at 120 inbreeded white rats (females, weight 120-125 g, age 2-3 month) infected by malignant Rhabdomyoma strain at the dose of 10 000 cells. Medical-biological tests show that the duration of anticancer activity for the drug-containing alginate microparticles increases at 5-8 times in comparison of free drugs. Such systems may have potential for controlled delivery of antitumor drugs for the treatment of eye cancer

Keywords

biomaterialnanostructurepolymer
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1209: Symposia P/YY – Business and Safety Issues in the Commercialization of Nanotechnology , 2009 , 1209-YY03-04
Copyright
Copyright © Materials Research Society 2010

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