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Application of Conductive Polymers in Bone Regeneration

Published online by Cambridge University Press:  15 February 2011

V.P. Shastri ,
N. Rahman ,
I. Martin  and
R. Langer
V.P. Shastri
Affiliation:
Departments of Chemical Engineering and Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139
N. Rahman
Affiliation:
Departments of Chemical Engineering and Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139
I. Martin
Affiliation:
Harvard-MIT Division of Health Sciences Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, email: prasha@mit.edu
R. Langer
Affiliation:
Departments of Chemical Engineering and Materials Science, Massachusetts Institute of Technology, Cambridge, MA 02139
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Abstract

The role of electromagnetism in the physiology of the human body and in the healing process is well accepted. Electroactive polymers, such as electrically conducting polymers, by virtue of their susceptibility to either electrical, mechanical, optical or thermal phenomena, could be utilized as an interface between the external world and the physiological environment1. In this study we have evaluated the utility of polypyrrole (PPy)-a conductive polymer, as an interactive substrate for inducing differentiation in bovine bone marrow stromal cells (BMSC). It was observed, the PPy is an excellent substrate for BMSC attachment, proliferation and differentiation. Furthermore, an application of an electrical stimulus (ES) to BMSC via PPy substrate was found to enhance the osteogenic commitment of these cells.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 215
Copyright
Copyright © Materials Research Society 1999

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References

1. Shastri, V. & Pishko, M. in Electrical and optical polymer systems (ed. Wise, D.L. et al. ) 1031–1051 (Marcel Dekker, Inc., New York, 1998).Google Scholar
2. Habal, M. & Reddi, H. Bone Grafts and Bone Graft Substitutes (W.B. Saunders Company, New York, 1992).Google Scholar
3. Langer, R. & Vacanti, J.P. Science. 260, 920–926 (1993).Google Scholar
4. Yasuda, I. J. Kyoto Pref. Univ. Med. 53, 325 (1953).Google Scholar
5. Shastri, V., Schmidt, C., Kim, T.-H., Vacanti, J. & Langer, R. Mat. Res. Soc. Symp. Proc. 414, 113–117 (1996).Google Scholar
6. Shastri, V., Schmidt, C., Langer, R. & Vacanti, J., United States Patent application, Assignee: Massachusetts Institute of Technology (1995).Google Scholar
7. Schmidt, C., Shastri, V., Vacanti, J. & Langer, R. Proc. Nati. Acad. Sci. USA. 94, 8948–8953 (1997).Google Scholar
8. Jaiswal, N., Haynesworth, S.E., Caplan, A.I. & Bruder, S.P. J. Cell. Biochem. 64, 295–312 (1997).Google Scholar
9. Martin, I., et al. in Orthopaedic Research Society (Anaheim, CA, 1999).Google Scholar
10. Prezyna, L., Qiu, Y.-J., Reynolds, J. & Wnek, G. Macromolecules. 24, 5283–5287 (1991).Google Scholar
11. Shastri, V. & Wnek, G. J. Biomed. Mat. Res. In review (1998).Google Scholar
12. Rouslahti, E. & Pierschbacher, M.D. Science. 238, 491–497 (1987).Google Scholar
13. Folkman, J. & Moscona, A. Nature. 273, 345–349 (1978).Google Scholar
14. Dunn, J.C.Y., Yarmush, M.C., Koebe, H.G. & Tompkins, R.G. FASEB J. 3, 174–177 (1989).Google Scholar