Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-25T17:58:10.639Z Has data issue: false hasContentIssue false
  • English
  • Français

Collagen as a Biomaterial: An Application in Knee Meniscal Fibrocartilage Regeneration

Published online by Cambridge University Press:  15 February 2011

Shu-Tung Li ,
Debbie Yuen ,
Peggy C. Li ,
William G. Rodkey  and
Kevin R. Stone
Shu-Tung Li
Affiliation:
ReGen Biologics, Inc., Franklin Lakes, NJ
Debbie Yuen
Affiliation:
ReGen Biologics, Inc., Franklin Lakes, NJ
Peggy C. Li
Affiliation:
ReGen Biologics, Inc., Franklin Lakes, NJ
William G. Rodkey
Affiliation:
Vail, CO
Kevin R. Stone
Affiliation:
San Francisco, CA USA
Get access

Abstract

Fibrous type I collagen possesses unique physicochemical, mechanical and biological properties which are useful for biomedical applications. Our research in applying collagen materials for various tissue repair has led to the development of a resorbable collagen based implant for meniscal tissue regeneration applications. We discuss here the design and development of this resorbable collagen based implant. The results of safety and efficacy studies indicate that the collagen based implant, if designed properly, can be a safe and effective template to support meniscal tissue regeneration in the knee joint.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 331: Symposium T – Biomaterials for Drug and Cell Delivery , 1993 , 25
Copyright
Copyright © Materials Research Society 1994

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Li, S.T., in Biotechnological Polymers, edited by Gebelein, C.G. (Technomic Publishing Co., Inc., Lancaster, PA, 1993) pp. 66–82.Google Scholar
2. Nimni, M.E. and Hardness, R.D., in Collagen, vol. I, edited by Nimni, M.E. (CRC Press Inc., Boca Raton, FL, 1988) pp. 1–35.Google Scholar
3. Glaser, J.H. and Conrad, H.E., J. Biol. Chem. 254, 2316 (1979).Google Scholar
4. Tripartite guidance for medical devices, prepared by Tripartite Sub-Committee on Medical Devices, Department of Health and Human Services, September, 1986.Google Scholar
5. Stone, K.R., Rodkey, W.G., Webber, R. et al., Am. J. Sports Med. 20, 104 (1992).Google Scholar
6. Folkman, J. and Moscona, A., Nature 273, 345 (1978).Google Scholar
7. Katz, E.P. and Li, S.T., J. Mol. Biol. 73, 351 (1973).Google Scholar
8. The United States Pharmacopeia, U.S. Pharmacopeial Convention, Inc., Rockville, MD, 1990.Google Scholar
9. Ames, B.N., McCann, J. and Yamasaki, E., Mut. Res. 31, 347–364 (1975).Google Scholar
10. Current Protocols in Immunology, edited by Coligan, J.E., Kruisbeek, A.M., Margulies, D.H., , E.M. et al. (John Wiley & Sons, New York, 1991) sections 2.1, 2.4, 3.1, and 3.12.Google Scholar