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Functionalization of Nanofibrous Spiral Structured Scaffolds for Bone Tissue Engineering

Published online by Cambridge University Press:  31 January 2011

Junping Wang  and
Xiaojun Yu
Junping Wang
Affiliation:
jwang16@stevens.edu, Stevens Institute of Technology, Biomedical Engineering, Hoboken, New Jersey, United States
Xiaojun Yu
Affiliation:
xyu@stevens.edu, Stevens Institute of Technology, Biomedical Engineering, Hoboken, New Jersey, United States
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Abstract

In the previous studies, we have successfully developed a novel spiral structured nanofibrous scaffolds with improved osteoconductivity for bone tissue engineering. The spiral structure design facilitates the nutrient transport and waste removal, and allows uniform cellular growth and distribution within the scaffolds, thus enhanced the bioactivity of the scaffolds. In this chapter, HAP and BMP-2 were incorporated within the nanofibrous spiral scaffolds in order to enhance the osteoinductivity of the established system. The effect of the blending materials was evaluated through cell proliferation, cell differentiation of human osteoblast cells seeded on the scaffolds and cultured for 4 and 8 days. The results has demonstrated that the functionalization of PCL nanofibrous spiral scaffolds leads to higher ALP expression level and increased amount of mineralization level however lower cell proliferation rate.

Keywords

bonenanostructurebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1235: Symposium RR – Engineering Biomaterials for Regenerative Medicine , 2009 , 1235-RR03-41
Copyright
Copyright © Materials Research Society 2010

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