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In vivo degradation behavior of PDC multiblock copolymers containing poly(para-dioxanone) hard segments and crystallizable poly(epsilon-caprolactone) switching segments

Published online by Cambridge University Press:  31 January 2011

Bernhard Hiebl ,
Karl Kratz ,
Rosemarie Fuhrmann ,
Friedrich Jung ,
Andres Lendlein  and
Ralf-Peter Franke
Bernhard Hiebl
Affiliation:
bernhard.hiebl@gkss.de, Berlin-Brandenburg-Centre for Regenerative Therapies, Bio-Engineering, Berlin, Berlin, Germany
Karl Kratz
Affiliation:
karl.kratz@gkss.de, Institute of Polymer Research, GKSS Research Center, Teltow, Germany
Rosemarie Fuhrmann
Affiliation:
rosemarie.fuhrmann@uni-ulm.de, University of Ulm, Department for Biomaterials, Ulm, Bayern, Germany
Friedrich Jung
Affiliation:
friedrich.jung@gkss.de, Berlin-Brandenburg-Centre for Regenerative Therapies, Bio-Engineering, Berlin, Berlin, Germany
Andres Lendlein
Affiliation:
lendlein@scholarone.com, United States
Ralf-Peter Franke
Affiliation:
ralf-peter.franke@uni-ulm.de, Institute of Polymer Research, GKSS Research Center, Teltow, Germany
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Abstract

The degradation behavior of biodegradable multiblock copolymers (PDC) containing poly(p-dioxanone) hard segments (PPDO) and crystallizable poly(epsilon-caprolactone) switching segments (PCL) synthesized via co-condensation of two oligomeric macrodiols with an aliphatic diisocyanate as junction unit was explored in in vivo and in vitro experiments. The in vitro experiments for enzymatic degradation resulted that the poly(epsilon-caprolactone) segments are degraded faster, than the poly(p-dioxanone) segments. During degradation the outer layer of the test specimen becomes porous. Finally non-soluble degradation products in form of particles were found at the surface. This observation is in good agreement with the in vivo studies, where the non-soluble degradation products in the periimplantary tissues showed a diameter of 1 – 3 micron.

Keywords

polymertissuebiomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1190: Symposium NN – Active Polymers , 2009 , 1190-NN06-05
Copyright
Copyright © Materials Research Society 2009

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