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MAPLE Direct Write (DW) patterning of Bio-active Ceramic Nanocomposites

Published online by Cambridge University Press:  01 February 2011

A. Doraiswamy ,
T. M. Patz ,
R. J. Narayan ,
L. Harris ,
R. Auyeung ,
R. Modi  and
D. B. Chrisey
A. Doraiswamy
Affiliation:
Bioengineering Program & School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
T. M. Patz
Affiliation:
Bioengineering Program & School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
R. J. Narayan
Affiliation:
Bioengineering Program & School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
L. Harris
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
R. Auyeung
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
R. Modi
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
D. B. Chrisey
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
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Abstract

A laser-based approach, Matrix Assisted Pulsed Laser Direct Write (MAPLE) technique is used to demonstrate two-dimensional direct writing of ceramics such as hydroxyl-apatite and zirconia, for developing inorganic scaffolds. We also demonstrate the patterning of live MG63 osteoblast cells onto various substrates. Our results show successful direct writing of ceramics and live cells concurrently, with a growth profile similar to that of as-deposited cells. After several days of growth, a live/dead assay shows live cells suggesting the biocompatibility of the ceramic and the viability of the process. This investigation demonstrates a novel method of developing heterogeneous tissue scaffolds, such as a cell-ceramic composite by CAD/CAM patterns.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA5.42
Copyright
Copyright © Materials Research Society 2005

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References

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