Hostname: page-component-7bb8b95d7b-w7rtg Total loading time: 0 Render date: 2024-10-02T17:21:27.158Z Has data issue: false hasContentIssue false
  • English
  • Français

Medical Applications of Water-Soluble Polyhydroxylated Fullerene Derivatives

Published online by Cambridge University Press:  15 February 2011

Long Y. Chiang ,
Fung-Jou Lu  and
Jaw-Town Lin
Long Y. Chiang
Affiliation:
Center for Condensed Matter Sciences, National Taiwan University, Taipei, Taiwan
Fung-Jou Lu
Affiliation:
Department of Biochemistry, College of Medicine, National Taiwan University, Taipei, Taiwan
Jaw-Town Lin
Affiliation:
Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan
Get access

Abstract

The promising positive results in reducing superoxide free radicals (O2-.), generated by invitro xanthine and xanthine oxidase, have been demonstrated in the evaluation of potential uses of novel water-soluble [60] fullerenols as free radical scavengers. Observation reveals the inherent application of fullerenols in a wide range of medical and clinical areas as preventive alternatives for a long-term medical treatment.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 359: Symposium G – Science and Technology of Fullerene Materials , 1994 , 327
Copyright
Copyright © Materials Research Society 1995

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

(1) For review of fullerene functionalization chemistry see: Taylor, R.; Walton, D. R. M. Nature 1993, 363, 685.Google Scholar
(2) Krusic, P. J.; Wasserman, E.; Keizer, P. N.; Morton, J. R.; Preston, K. F. Science 1991, 254, 1183.Google Scholar
(3) Chiang, L. Y.; Swirczewski, J. W.; Hsu, C. S.; Chowdhury, S. K.; Cameron, S.; Creegan, K. J. Chem. Soc., Chem. Commun. 1992, 1791.Google Scholar
(4) Chiang, L. Y.; Wang, L. Y.; Swirczewski, J. W.; Soled, S.; Cameron, S. J. Org. Chem. 1994, 59, 3960.Google Scholar
(5) Chiang, L. Y.; Upasani, R. B.; Swirczewski, J. W. U.S. Patent 5,177,248, 1993; U.S. Patent 5,294,732, 1994.Google Scholar
(6) Chiang, L. Y.; Lu, F. J.; Lin, J. T. to be published.Google Scholar
(7) Friedman, S. H.; DeCamp, D. L.; Sijbesma, R. P.; Srdanov, G.; Wudl, F.; Kenyon, G. L. J. Am. Chem. Soc. 1993, 115, 6506.Google Scholar
(8) Tokuyama, H.; Yamago, S.; Nakamura, E. J. Am. Chem. Soc. 1993, 115, 7918.Google Scholar
(9) Chiang, L. Y.; Upasani, R. B.; Swirczewski, J. W. J. Am. Chem. Soc. 1992, 114, 10154.Google Scholar
(10) Chiang, L. Y.; Upasani, R. B.; Swirczewski, J. W.; Soled, S. J. Am. Chem. Soc. 1993, 115, 5453.Google Scholar