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Microstructural Characterization of Polyanhydride Blends for Controlled Drug Delivery

Published online by Cambridge University Press:  15 March 2011

Elizabeth E. Shen ,
Hsin-Lung Chen  and
Balaji Narasimhan
Elizabeth E. Shen
Affiliation:
Department of Chemical & Biochemical EngineeringRutgers University98 Brett Road Piscataway, NJ 08854, U.S.A
Hsin-Lung Chen
Affiliation:
Department of Chemical EngineeringNational Tsing-Hua University Hsinchu, Taiwan
Balaji Narasimhan
Affiliation:
Department of Chemical & Biochemical EngineeringRutgers University98 Brett Road Piscataway, NJ 08854, U.S.A
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Abstract

This research examines the microstructure of polyanhydride blends for use in drug delivery devices. Atomic force microscopy (AFM) and small-angle X-ray scattering (SAXS) studies were performed on the homopolymers and blends of the polyanhydrides poly(1,6-carboxyphenoxy hexane) (CPH) and poly(sebacic anhydride) (SA). AFM of the CPH/SA blends 20:80, 50:50, and 80:20 showed distinct patterns indicating spinodal decomposition and phase separation on the micron-scale. Because it has been shown that incorporated drugs will thermodynamically partition into phase-separated domains depending on their hydrophobicity, polyanhydride blends will be able to encapsulate larger bioactive compounds including nucleotides, proteins, and vaccines. Preliminary SAXS studies of the CPH/SA blend systems provide information on the crystalline morphology of the polymer. A peak shift to a lower q from poly(SA) to the blends indicates that the poly(CPH) is incorporated into and causes swelling of the interlamellar amorphous regions of poly(SA).

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 662: Symposia LL/MM/NN/OO – Biomaterials for Drug Delivery & Tissue Engineering , 2000 , NN4.2
Copyright
Copyright © Materials Research Society 2001

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