Hostname: page-component-7479d7b7d-pfhbr Total loading time: 0 Render date: 2024-07-08T08:24:29.135Z Has data issue: false hasContentIssue false
  • English
  • Français

Osteoblast Attachment on Biomaterials as a Function of Surface Charge

Published online by Cambridge University Press:  15 February 2011

M. Marcolongo ,
N. J. Dinardo ,
N. Hickok ,
R. Tuan ,
K. Pourezzaei ,
R. Beard ,
D. Brennan ,
P. Heipp  and
T. Phan
M. Marcolongo
Affiliation:
Departments of Materials EngineeringDrexel University, Philadelphia, PA 19104
N. J. Dinardo
Affiliation:
Departments of PhysicsDrexel University, Philadelphia, PA 19104
N. Hickok
Affiliation:
Department of Orthopaedic Surgery Research, Thomas Jefferson University, Philadelphia, PA 19107
R. Tuan
Affiliation:
Department of Orthopaedic Surgery Research, Thomas Jefferson University, Philadelphia, PA 19107
K. Pourezzaei
Affiliation:
Departments of Materials Electrical EngineeringDrexel University, Philadelphia, PA 19104
R. Beard
Affiliation:
Departments of Materials Electrical EngineeringDrexel University, Philadelphia, PA 19104
D. Brennan
Affiliation:
Departments of PhysicsDrexel University, Philadelphia, PA 19104
P. Heipp
Affiliation:
Departments of Materials Biomedical EngineeringDrexel University, Philadelphia, PA 19104
T. Phan
Affiliation:
Departments of Materials Chemical Engineering, Drexel University, Philadelphia, PA 19104
Get access

Abstract

Bioactive materials such as calcium phosphate ceramics and bioactive glasses enhance bone tissue formation and then bond to bone tissue. In our work, we question what particular surface feature or features of bioactive materials are responsible for the bone tissue response. In this study we have uncoupled surface charge from surface chemistry, energy, and topography and have examined osteoblast adhesion to titanium surfaces of varying surface charge. We have shown that a negative surface charge promotes osteoblast adhesion by approximately 60% over a neutral surface and that conversely, a positive surface charge inhibits osteoblast adhesion by about 20%. Continued examination of surface characteristics that control cellular responses are warranted with the eventual goal of applying those desirable surface characteristics to any structural biomaterial for bone implant or tissue engineering applications.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 121
Copyright
Copyright © Materials Research Society 1999

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Pizzoferrato, A., Ciapetti, G., Stea, S., and Toni, A., Clin. Mater. 7, p. 51 (1991).Google Scholar
2. Cook, S. D. and Thomas, K. A., Soc. for Biomat. 273 (1990).Google Scholar
3. Thomas, K. A., Cook, S. D., Haddad, R. J. and Thomas, K. L., 33rd Annual ORS: 432 (1987).Google Scholar
4. Hench, L. L. and Wilson, J., ed., An Introduction to Bioceramics, World Scientific, London, 1993.Google Scholar
5. Pollack, S. R., Clin. Orthop. N. A. 15, p. 3 (1984).Google Scholar
6. Seyfert, S., Boigt, A., and , Kabbeck-Kupijai, Biomaterials, 16, p. 201 (1995).Google Scholar
7. Lin, W., Garnett, M. C., Davies, M. C. et al. , 18, p. 559 (1997).Google Scholar
8. Shelton, R. M., Rasmussen, A. C. and Davies, J. E., Biomaterials 9, p. 24 (1988).Google Scholar
9. Fujimoto, K., Tadokoro, H., Ueda, Y. and Ikada, Y., Biomaterials 14, p. 442 (1993).Google Scholar
10. Hunter, R. J., Zeta Potential in Colloid Science: Principles and Applications, Academic Press, London (1981).Google Scholar
11. Hench, L. L., Splinter, R., Greenlee, T. and Allen, W., J. Biomed. Mater. Res., 2. p. 117 (1971).Google Scholar
12. Anderson, O. H., Liu, G., Kangasniemi, K. and Juhanoja, J., Mater. in Med., 3, p. 145 (1992).Google Scholar
13. Marcolongo, M., Ducheyne, P., Garino, J. and Schepers, E., J. Biomed. Mater. Res. 38, p. 160 (1998).Google Scholar
14. Lu, H. Y., Pollack, S. R. and Ducheyne, P., Surfaces in Biomaterials, p. 24 (1995).Google Scholar